Results 21 to 30 of about 6,525,414 (422)
Antioxidants, 2021 Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise.
Marisa L. Henry +5 more
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Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis [PDF]
Nucleic Acids Research, 2012 Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods ...
He, J +11 more
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Mitochondrial protein homeostasis [PDF]
IUBMB Life, 2013 AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Diana Stojanovski +2 more
openaire +3 more sources
Nature Communications, 2020 Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles (EVs). While EVs are small vesicles that transfer material between cells, Mitochondria-Derived Vesicles (MDVs) carry material specifically between mitochondria and
K. Todkar +5 more
semanticscholar +1 more source
Reviews in Cardiovascular Medicine, 2022 Background: Humanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression decrease with age.
Maha Alser +9 more
doaj +1 more source
Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases
Biomolecules, 2021 Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera +3 more
doaj +1 more source
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis
Nature Communications, 2020 The Sorting and Assembly Machinery (SAM) complex folds beta-barrel proteins and inserts them into the mitochondrial outer membrane. Here authors report cryoEM structures of the SAM complex from Myceliophthora thermophila, which reveals a GST-like fold ...
Kathryn A. Diederichs +8 more
doaj +1 more source
IRE1 KNOCKDOWN MODIFIES THE GLUTAMINE AND GLUCOSE DEPRIVATION EFFECT ON THE EXPRESSION OF NUCLEAR GENES ENCODING MITOCHONDRIAL PROTEINS IN U87 GLIOMA CELLS [PDF]
Biotechnologia Acta, 2016 We have studied the glucose and glutamine deprivation effect on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. O. , D. O. , D. O. , O.O. , O. H.
doaj +1 more source
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
eLife, 2022 Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu +5 more
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Copper induces cell death by targeting lipoylated TCA cycle proteins
Science, 2022 Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov +17 more
semanticscholar +1 more source