Results 171 to 180 of about 26,194 (236)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. [PDF]

Cancers (Basel), 2021
Buyse C, Joudiou N, Corbet C, Feron O, Mignion L, Flament J, Gallez B.   +6 more
europepmc   +1 more source

Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington’s disease [PDF]

Ângela Z. Oliveira, Liliana M. Almeida, Michael Ollmann, Brígida R. Pinho   +3 more
openalex   +1 more source

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death [PDF]

, 2017
Ajit S. Divakaruni, Martina Wallace, Caodu Buren, Kelly Martyniuk, Alexander Y. Andreyev, Edward Li, Jerel Adam Fields, Thekla Cordes, Ian J. Reynolds, Brenda L. Bloodgood, Lynn A. Raymond, Christian M. Metallo, Anne N. Murphy   +12 more
openalex   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Postexercise Lactate Clearance, T2 Relaxation, and J‐Modulation in Human Skeletal Muscle Measured With Double‐Quantum Filtered 1H MRS at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose 1H MRS lactate measurements are potentially valuable for studying energy metabolism in working skeletal muscle, but some technical obstacles need to be overcome. Spectral filtering to isolate the lactate signal from overlapping lipid resonances shows promise.
Kostiantyn Repnin, Vasco Rafael Rocha dos Santos, Veronika Cap, Roberta Frass‐Kriegl, Siegfried Trattnig, Graham J. Kemp, Martin Meyerspeer   +6 more
wiley   +1 more source

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.

Cell Metab, 2022
Wenes M, Jaccard A, Wyss T, Maldonado-Pérez N, Teoh ST, Lepez A, Renaud F, Franco F, Waridel P, Yacoub Maroun C, Tschumi B, Dumauthioz N, Zhang L, Donda A, Martín F, Migliorini D, Lunt SY, Ho PC, Romero P.   +18 more
europepmc   +1 more source

Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Although classically characterized as a motor neuron disease, spinal muscular atrophy (SMA) is increasingly recognized as a multisystem disorder. We previously showed hepatocyte‐intrinsic steatosis in SMA, raising the question of whether SMA carriers, who are typically asymptomatic, may also exhibit subclinical hepatic ...
Lingyu Sun, Damien Meng Kiat Leow, Loo Chien Wang, Michelle Yating Eio, Hiromi W. L. Koh, Zi Jian Khong, Gunaseelan Narayanan, Aloysius Kai Soon Teo, Richard Giadone, Radoslaw M. Sobota, Shi Yan Ng, Adrian Kee Keong Teo, Wei Yi Ong, Lee L. Rubin, Basil T. Darras, Crystal J. J. Yeo   +15 more
wiley   +1 more source

SLC54 Mitochondrial pyruvate carriers (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

, 2020
Calum Wilson
openalex   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source