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Mitochondrial Handling of Excess Ca\u3csup\u3e2+\u3c/sup\u3e is Substrate-dependent with Implications for Reactive Oxygen Species Generation [PDF]

, 2013
The mitochondrial electron transport chain is the major source of reactive oxygen species (ROS) during cardiac ischemia. Several mechanisms modulate ROS production; one is mitochondrial Ca2+ uptake.
Aldakkak, Mohammed +3 more
core +1 more source

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis

Nature Communications
The competitive advantage of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH). Drivers of CH include aging and inflammation; however, how CH-mutant cells gain a selective advantage in these contexts is an ...
Kira A. Young +20 more
doaj +1 more source

Putative Molecular Mechanisms Underpinning the Inverse Roles of Mitochondrial Respiration and Heme Function in Lung Cancer and Alzheimer’s Disease

Biology
Mitochondria are the powerhouse of the cell. Mitochondria serve as the major source of oxidative stress. Impaired mitochondria produce less adenosine triphosphate (ATP) but generate more reactive oxygen species (ROS), which could be a major factor in the
Atefeh Afsar, Li Zhang
doaj +1 more source

A novel extracellular flux assay workflow uncovers impaired sciatic nerve mitochondrial respiration in diabetic db/db mice

Cell Communication and Signaling
Abnormal mitochondrial function contributes to the development of diabetic neuropathy by inducing oxidative stress and altering energy metabolism, ultimately leading to neuronal damage.
Sebastian Sill +9 more
doaj +1 more source

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. [PDF]

, 2019
Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in ...
Arredondo, Juan +13 more
core

In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds

iScience
Summary: Mitochondrial abnormalities drive subcutaneous white adipose tissue dysfunction in obesity, yet in vitro models to study adipocyte mitochondria remain limited.
Anita Wagner +24 more
doaj +1 more source

SKELETAL MUSCLE MITOCHONDRIAL OXIDATIVE CAPACITY AND UNCOUPLING PROTEIN 3 ARE DIFFERENTLY INFLUENCED BY SEMISTARVATION AND REFEEDING [PDF]