Results 81 to 90 of about 645,590 (301)

The Use of Triphenyl Phosphonium Cation Enhances the Mitochondrial Antiplatelet Effect of the Compound Magnolol

, 2023
Although platelets are anucleated cells, they have fully functional mitochondria, and currently, it is known that several processes that occur in the platelet require the action of mitochondria.
Eduardo Fuentes, Laura Castro, Santiago Mansilla, Magdalena Sepúlveda, Diego Méndez, Ramiro Araya-Maturana, Andrés Trostchansky, Francisca Tellería, Tellería, Francisca, Sepúlveda, Magdalena, Araya-Maturana, Ramiro, Trostchansky, Andrés, Mansilla, Santiago, Méndez, Diego, Castro, Laura, Fuentes, Eduardo   +15 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Methionine supplementation stimulates mitochondrial respiration [PDF]

, 2018
Mitochondria play essential metabolic functions in eukaryotes. Although their major role is the generation of energy in the form of ATP, they are also involved in maintenance of cellular redox state, conversion and biosynthesis of metabolites and signal ...
Airoldi, Cristina, Scarcia P, Maffioli E, Palmieri L, Castoldi A, Falletta E, Tripodi, Farida, Reghellin V, Tedeschi G, Nicastro R, Agrimi G, Castoldi, Andrea, Lombardi, Linda, Lombardi L, Airoldi C, Nicastro, Raffaele, Scarcia, Pasquale, Tripodi F, Reghellin, Veronica, Alberghina L, Tedeschi, Gabriella, Coccetti P, Maffioli, Elisa, Falletta, Ermelinda, Agrimi, Gennaro, Alberghina, Lilia, Coccetti, Paola, Palmieri, Luigi   +27 more
core   +1 more source

Effects of NO on mitochondrial oxygen respiration.

, 2022
n = 5. Seahorse measurements of the effects of NO on mitochondrial oxygen consumption rate (OCR). A) Example (control group) for the Seahorse assay of mitochondrial OCR.
Carolyn Fall (12530381), Beatriz Tone (12530399), Saburi Eliamani (12530402), Johnny D. Figueroa (12530393), Taiming Liu (12530408), Barbara Holshouser (12530405), Christopher G. Wilson (583691), Aditi Bhanot (12530390), Euntaik Ha (12530378), Peter Jung (47928), Samuel Stetkevich (12530387), Emily Taylor (5236982), Mindy Hwang (12530384), Shannon Bragg (12530396), Meijuan Zhang (389935), Arlin B. Blood (11958128), Andre Obenaus (475846)   +16 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Heightened mitochondrial respiration in CF cells is normalised by triple CFTR modulator therapy through mechanisms involving calcium

Heliyon
Background: Cystic fibrosis (CF) is associated with increased resting energy expenditure. However, the introduction of elexacaftor/tezacaftor/ivacaftor (ETI) has resulted in a paradigm shift in nutritional status for many people with CF, with increase ...
H.H. Jarosz-Griffiths, L.R. Caley, S. Lara-Reyna, S. Savic, I.J. Clifton, M.F. McDermott, D.G. Peckham   +6 more
doaj   +1 more source

Heat death and the development of thermotolerance in the blow fly calliphora viicina: a study of flight muscle mitochondrial function [PDF]

, 1996
The LD(_50) of 10-day-old blowflies differed significantly in two different stocks, and were found to be 38.12 ± 0.07ºC for the Durham stock and 40.8 ± 0.18ºC for the Cambridge stock.
El-Wadawi, Rukaya A.
core  

Parameters of mitochondrial respiration reduced on induction of UCP1-shRNA.

, 2019
(a) Derived parameters of mitochondrial respiration across control and Rosiglitazone viral-transfected cells ± dox. (b) Basal and maximal glycolysis. (c) Percentage decrease in respiration, induced with UCP1-shRNA.
Nicole Wen Mun Khor (7907894), Michael M. Swarbrick (7907897), Jenny E. Gunton (7907900)   +2 more
core   +1 more source

Reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy [PDF]

, 2013
Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce.
Miró Meda, José M. (José María), 1956-, Cardellach, Francesc, López Moreno, Sònia, Martínez, Esteban, Blanco, José L., Milinkovic, Ana, Rodríguez Santiago, Benjamín, Gatell, José M., Nunes Martínez, Virginia, Casademont i Pou, Jordi, Miró i Andreu, Òscar   +10 more
core   +1 more source