Results 91 to 100 of about 645,590 (301)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Altered Peripheral Blood Mononuclear Cell (PBMC) Mitochondrial Coupling and Complex IV Respiration in Severe Aortic Stenosis Before and After Transcatheter Aortic Valve Replacement (TAVR)

Journal of Cardiovascular Development and Disease
Background: Circulating peripheral blood mononuclear cell (PBMC) mitochondrial respiration is impaired in heart failure and transplanted patients.
Benjamin Marchandot, Anne-Laure Charles, Kerem Demir, Cedric Momas, Samy Talha, Michel Kindo, Patrick Ohlmann, Margherita Giannini, Alain Meyer, Olivier Morel, Bernard Geny   +10 more
doaj   +1 more source

The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease

Redox Biology, 2016
Background: Mitochondrial dysfunction and bioenergetic stress play an important role in the etiology of alcoholic liver disease. Previous studies from our laboratory show that the primary methyl donor S-Adenosylmethionine (SAM) minimizes alcohol-induced ...
Adrienne L. King, Sudheer K. Mantena, Kelly K. Andringa, Telisha Millender-Swain, Kimberly J. Dunham-Snary, Claudia R. Oliva, Corinne E. Griguer, Shannon M. Bailey   +7 more
doaj   +1 more source

Reactivation of dihydroorotate dehydrogenase by respiration restores tumor growth of mitochondrial DNA-depleted cancer cells

, 2018
Background: Cancer cells without mitochondrial DNA (mtDNA) need to reconstitute oxidative phosphorylation (OXPHOS) by acquisition of host mitochondria to form tumors (1,2), but the reasons why functional respiration is crucial for tumorigenesis remain ...
Maghzal, GJ, Park, S, Neuzil, J, Coelho, A, Stocker, R, Kovarova, J, Oh, S, Svec, D, Judasova, K, Bajzikova, M, Hubackova, S, Rohlenova, K, Boukalova, S, Dong, L, Rohlena, J, Oliveira, P, Berridge, MV   +16 more
core   +1 more source

Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion [PDF]

, 2003
Fertilization increases both cytosolic Ca(2+) concentration and oxygen consumption in the egg but the relationship between these two phenomena remains largely obscure.
Smith, Peter J., Cibert, Christian, Porterfield, Marshall, Rouviere, Christian, Sardet, Christian, Hammar, Katherine, Porterfield, D. Marshall, Smith, Peter J. S., Dumollard, Remi, Hammar, Katherine M.   +9 more
core   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Nitric Oxide Does Not Improve Liver Mitochondrial Function 48 Hours After Cecal Ligation and Perforation in Experimental Sepsis

Antioxidants
Nitric oxide (NO) has a dual effect on mitochondria. Incubating liver mitochondria with NO improves oxidative phosphorylation (OXPHOS) efficiency by decreasing state 4 respiration more than ATP synthesis and preventing mitochondrial permeability ...
Pierre Eyenga, Shey-Shing Sheu
doaj   +1 more source

Summary of day 10 endurance, speed and mitochondrial respiration data with NR feeding.

, 2023
Summary of day 10 endurance, speed and mitochondrial respiration data with NR feeding.
Kristin Richardson (17054726), Robert Wessells (263484)   +1 more
core   +1 more source