Results 101 to 110 of about 645,590 (301)

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Altered Mitochondrial Respiration in Peripheral Blood Mononuclear Cells of Post-Acute Sequelae of SARS-CoV-2 Infection [PDF]

Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20).
Mccomsey, Grace A, Durieux, Jared C, Dirajlal-Fargo, Sahera   +2 more
core   +1 more source

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro

, 2006
INTRODUCTION: Mitochondrial respiration is impaired during endotoxemia. While catecholamines are frequently used in sepsis, their effects on mitochondrial function are controversial.
Weikert, Christian, Kaufmann, Priska, Krahenbuhl, Stephan, Jakob, Stephan M, Porta, Francesca, Takala, Jukka, Jakob SM, Jakob, Stephan, Krahenbuhl S, Kaufmann P, Weikert C, Jakob, Stephan M., Takala J, Porta F   +13 more
core   +1 more source

Mitochondrial respiration is reduced in atherosclerosis, promoting necrotic core formation and reducing relative fibrous cap thickness [PDF]

, 2017
OBJECTIVE: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving ...
Uryga, Anna K., Pung, Yuh-Fen, Johannes Reinhold, Martin Bennett, Murphy, Michael P., Anna K. Uryga, Figg, Nichola, Yu, Emma P. K., Lakshi Starks, Nichola Figg, Michael P. Murphy, Reinhold, Johannes, Foote, Kirsty, Angela Logan, Logan, Angela, Bennett, Martin, Emma P.K. Yu, Haixiang Yu, Kirsty Foote, Yu, Haixiang, Finigan, Alison, Yuh-Fen Pung, Starks, Lakshi, Alison Finigan   +23 more
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities

Stem Cell Research & Therapy, 2018
Background Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease.
Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal, Sujata Mohanty   +3 more
doaj   +1 more source

Mitochondrial respiration.

, 2016
The rate of oxygen consumption in different states of mitochondrial respiration. Cardiac HL-1 cells were incubated either under normal conditions or with an amino acid-free and serum-free starvation buffer for 24h with or without UA-8 (1μM) and 14,15 ...
Nasser Alsaleh (2020066), John R. Falck (452496), Haitham E. El-Sikhry (3142377), John M. Seubert (2020063), Rambabu Dakarapu (2719939)   +4 more
core   +1 more source

Mitochondrial respiration is reduced in atherosclerosis, promoting necrotic core formation and reducing relative fibrous cap thickness [PDF]

, 2018
Objective: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction, and whether decreasing mtDNA damage and improving ...

core   +3 more sources

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source