Results 61 to 70 of about 491,817 (253)

Functional hypoxia reduces mitochondrial calcium uptake

Redox Biology
Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate
Chris Donnelly, Timea Komlódi, Cristiane Cecatto, Luiza H.D. Cardoso, Anne-Claire Compagnion, Alessandro Matera, Daniele Tavernari, Olivier Campiche, Rosa Chiara Paolicelli, Nadège Zanou, Bengt Kayser, Erich Gnaiger, Nicolas Place   +12 more
doaj   +1 more source

Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

Molecular Metabolism, 2018
Objective: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the ...
Evan P. Taddeo, Linsey Stiles, Samuel Sereda, Eleni Ritou, Dane M. Wolf, Muhamad Abdullah, Zachary Swanson, Josh Wilhelm, Melena Bellin, Patrick McDonald, Kacey Caradonna, Andrew Neilson, Marc Liesa, Orian S. Shirihai   +13 more
doaj   +1 more source

Sex differences and estrogen effects in cardiac mitochondria in human aortic stenosis and in the mouse heart

Frontiers in Endocrinology, 2023
IntroductionSex differences in the adaptation to pressure overload have been described in humans, as well as animal models, and have been related to sex-specific expression of mitochondrial genes.
Daniela Fliegner, Daniela Fliegner, Alexandra Ellieva, Anja Angelov, Georgi Petrov, Vera Regitz-Zagrosek, Vera Regitz-Zagrosek   +6 more
doaj   +1 more source

Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants [PDF]

, 2014
Idiosyncratic drug-induced liver injury is a rare toxic event that typically occurs at therapeutic doses, which are generally safe to the majority of patients.
Felser, Andrea Debora
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Reduced Citrate Synthase Activity Effect on Oxygen Consumption Rates in Isolated Mitochondria from Mice Liver and Muscles

Baltic Journal of Sport and Health Sciences, 2018
Background. Liver and skeletal muscles play the major role in metabolism. Mitochondria are of particular importance in functioning of these organs.
Andrej Fokin, Rasa Žūkienė, Aivaras Ratkevičius   +2 more
doaj   +1 more source

Kinetics of the inhibition of mitochondrial respiration by NO

FEBS Letters, 1997
The kinetics of the inhibition of mitochondrial respiration by NO was examined in isolated mitochondria (here obtained from rat brown adipose tissue). The K i of NO for the inhibition was ∼27 nM; the IC50 of NO increased in proportion to the square of an increase in O2 tension.
Koivisto, Ari, Matthias, Anita, Bronnikov, Gennady, Nedergaard, Jan   +3 more
openaire   +2 more sources

Bomb-14C analysis of ecosystem respiration reveals that peatland vegetation facilitates release of old carbon [PDF]

, 2009
The largest terrestrial-to-atmosphere carbon flux is respired CO2. However, the partitioning of soil and plant sources, understanding of contributory mechanisms, and their response to climate change are uncertain.
Fallick, A. E., Fallick, A.E., Ostle, N.J., Hardie, S.M.L., Garnett, M.H., Rowland, A. P., Rowland, A.P., Hardie, S. M.L., Garnett, M. H., Ostle, N. J.   +9 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source