Results 61 to 70 of about 645,590 (301)

Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51

Cell Reports, 2023
Summary: The mitochondrial response to changes in cellular energy demand is necessary for cellular adaptation and organ function. Many genes are essential in orchestrating this response, including the transforming growth factor (TGF)-β1 target gene Mss51,
Muhammad G. Mousa, Lahari Vuppaladhadiam, Meredith O. Kelly, Terri Pietka, Shelby Ek, Karen C. Shen, Gretchen A. Meyer, Brian N. Finck, Rita T. Brookheart   +8 more
doaj   +1 more source

Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents

, 2015
Respiration is one of the major functions of mitochondria, whereby these vital organelles use oxygen to produce energy. Many agents that may be of potential clinical relevance act by targeting mitochondria, where they may suppress mitochondrial ...
Martina Bajzikova, Neuzil, J, Dong, LF, Katarina Kluckova, Bajzikova, M, Lan-Feng Dong, Jakub Rohlena, Jiri Neuzil, Kluckova, K, Rohlena, J   +9 more
core   +1 more source

The mitochondrial elongation factor LeEF-Tsmt is regulated during tomato fruit ripening and upon wounding and ethylene treatment [PDF]

, 2006
A gene encoding an elongation factor LeEF-Tsmt that participates in the protein synthesis process in mitochondria shows strong expression in ripening fruit as compared to other organs.
Latché, Alain, Pech, Jean-Claude, Jaimes Miranda, Fabiola, Zouine, Mohamed, Girardi, Cesar Luis, Bermudez, Kalina, Bernadac, Anne, Chaves, Ana, Bouzayen, Mondher   +8 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Functional hypoxia reduces mitochondrial calcium uptake

Redox Biology
Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate
Chris Donnelly, Timea Komlódi, Cristiane Cecatto, Luiza H.D. Cardoso, Anne-Claire Compagnion, Alessandro Matera, Daniele Tavernari, Olivier Campiche, Rosa Chiara Paolicelli, Nadège Zanou, Bengt Kayser, Erich Gnaiger, Nicolas Place   +12 more
doaj   +1 more source

β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]

, 2004
β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y., Duchen, M.R., Canevari, L.   +2 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

Molecular Metabolism, 2018
Objective: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the ...
Evan P. Taddeo, Linsey Stiles, Samuel Sereda, Eleni Ritou, Dane M. Wolf, Muhamad Abdullah, Zachary Swanson, Josh Wilhelm, Melena Bellin, Patrick McDonald, Kacey Caradonna, Andrew Neilson, Marc Liesa, Orian S. Shirihai   +13 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Reduced Citrate Synthase Activity Effect on Oxygen Consumption Rates in Isolated Mitochondria from Mice Liver and Muscles

Baltic Journal of Sport and Health Sciences, 2018
Background. Liver and skeletal muscles play the major role in metabolism. Mitochondria are of particular importance in functioning of these organs.
Andrej Fokin, Rasa Žūkienė, Aivaras Ratkevičius   +2 more
doaj   +1 more source