Results 131 to 140 of about 491,817 (253)

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine

Intensive Care Medicine Experimental
Background Equivocal data exist on whether noradrenaline during resuscitation from circulatory shock affects tissue mitochondrial respiration. Therefore, we examined the relation between myocardial mitochondrial respiration and plasma noradrenaline ...
Nadja Abele, Tamara Merz, Fabian Zink, Andrea Hoffmann, Michael Gröger, Sandra Kress, Stefanie Kranz, Andrea Seifritz, Vittoria Passarelli, Franziska Münz, Maximilian Feth, Magnus Scheer, Ohad Sharon, Melanie Hogg, Eva-Maria Wolfschmitt, Ulrich Wachter, Tanja Schulz, Enrico Calzia, Nicolas Fage, Christiane Waller, Pierre Asfar, Peter Radermacher, Thomas Kapapa   +22 more
doaj   +1 more source

Putative Molecular Mechanisms Underpinning the Inverse Roles of Mitochondrial Respiration and Heme Function in Lung Cancer and Alzheimer’s Disease

Biology
Mitochondria are the powerhouse of the cell. Mitochondria serve as the major source of oxidative stress. Impaired mitochondria produce less adenosine triphosphate (ATP) but generate more reactive oxygen species (ROS), which could be a major factor in the
Atefeh Afsar, Li Zhang
doaj   +1 more source

The role of mitochondrial DNA in tumorigenesis [PDF]

Mitochondria are cytoplasmic organelles that are found in almost all mammalian cells. Mitochondria contain their own genome, mitochondrial DNA (mtDNA) that encodes 13 subunits of the electron transfer chain, which is the primary generator of cellular ...
Dickinson, Adam
core  

The relationship between mitochondrial respiration, resting metabolic rate and blood cell count in great tits

Although mitochondrial respiration is believed to explain a substantial part of the variation in resting metabolic rate (RMR), few studies have empirically studied the relationship between organismal and cellular metabolism. We therefore investigated the
Persson, Elin,, Carmen C. García-Díaz, Nord, Andreas,, Ruuskanen, Suvi, Ruuskanen, Suvi,, Elisa Thoral, Garcıá-Dıáz, Carmen C., Garcıá-Dıáz, Carmen C.,, Suvi Ruuskanen, Imen Chamkha, García-Díaz, Carmen, C, Chamkha, Imen,, Nord, Andreas, Andreas Nord, Persson, Elin, Thoral, Elisa, Chamkha, Imen, Elin Persson, Elmér, Eskil,, Eskil Elmér, Thoral, Elisa,, Lund University., Elmér, Eskil, García-Díaz, Carmen C.   +23 more
core   +1 more source

Mitochondrial respiration.

, 2016
The rate of oxygen consumption in different states of mitochondrial respiration. Cardiac HL-1 cells were incubated either under normal conditions or with an amino acid-free and serum-free starvation buffer for 24h with or without UA-8 (1μM) and 14,15 ...
Nasser Alsaleh (2020066), John R. Falck (452496), Haitham E. El-Sikhry (3142377), John M. Seubert (2020063), Rambabu Dakarapu (2719939)   +4 more
core   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis

Nature Communications
The competitive advantage of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH). Drivers of CH include aging and inflammation; however, how CH-mutant cells gain a selective advantage in these contexts is an ...
Kira A. Young, Mohsen Hosseini, Jayna J. Mistry, Claudia Morganti, Taylor S. Mills, Xiurong Cai, Brandon T. James, Griffin J. Nye, Natalie R. Fournier, Veronique Voisin, Ali Chegini, Aaron D. Schimmer, Gary D. Bader, Grace Egan, Marc R. Mansour, Grant A. Challen, Eric M. Pietras, Kelsey H. Fisher-Wellman, Keisuke Ito, Steven M. Chan, Jennifer J. Trowbridge   +20 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source