Results 51 to 60 of about 98,042 (158)

Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

Molecular Metabolism, 2018
Objective: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the ...
Evan P. Taddeo, Linsey Stiles, Samuel Sereda, Eleni Ritou, Dane M. Wolf, Muhamad Abdullah, Zachary Swanson, Josh Wilhelm, Melena Bellin, Patrick McDonald, Kacey Caradonna, Andrew Neilson, Marc Liesa, Orian S. Shirihai   +13 more
doaj   +1 more source

Functional hypoxia reduces mitochondrial calcium uptake

Redox Biology
Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate
Chris Donnelly, Timea Komlódi, Cristiane Cecatto, Luiza H.D. Cardoso, Anne-Claire Compagnion, Alessandro Matera, Daniele Tavernari, Olivier Campiche, Rosa Chiara Paolicelli, Nadège Zanou, Bengt Kayser, Erich Gnaiger, Nicolas Place   +12 more
doaj   +1 more source

Palmitate-Induced Cell Death and Mitochondrial Respiratory Dysfunction in Myoblasts are Not Prevented by Mitochondria-Targeted Antioxidants

Cellular Physiology and Biochemistry, 2014
Background/Aims: Deleterious effects of saturated fatty acids in skeletal muscle cells are well known but their impact on mitochondrial respiration has not been well studied.
Jana Patková, Michal Anděl, Jan Trnka
doaj   +1 more source

Dose-dependent regulation of kidney mitochondrial function by angiotensin II

Upsala Journal of Medical Sciences, 2023
Background: Intrarenal hypoxia has been suggested a unifying pathway to chronic kidney disease (CKD) and increased mitochondria leak respiration, which increases mitochondrial oxygen usage and is one important mechanism contributing to the development of
Ebba Sivertsson, Amanda Balboa, Tomas A Schiffer, Peter Hansell, Malou Friederich-Persson, Patrik Persson, Fredrik Palm   +6 more
doaj   +1 more source

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]

, 2014
In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V, Bertrand, Mathieu, Bruggeman, Inge, Dondelinger, Yves, Gonçalves, Amanda, Goossens, Vera, Grootjans, Sasker, Remijsen, Quinten, Roelandt, Ria, Takahashi, Nozomi, Van den Haute, C, Vanden Berghe, Tom, Vandenabeele, Peter, Vanlangenakker, Nele   +13 more
core   +3 more sources

High‐fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice

Physiological Reports, 2023
High‐fat diet (HFD) and exercise remodel skeletal muscle mitochondria. The electron transfer flavoproteins (ETF) transfer reducing equivalents from β‐oxidation into the electron transfer system.
Philip M. Batterson, Erin M. McGowan, Agnieszka K. Borowik, Michael T. Kinter, Benjamin F. Miller, Sean A. Newsom, Matthew M. Robinson   +6 more
doaj   +1 more source

Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. [PDF]

, 2015
The effects of environmental hypoxia on cardiac and skeletal muscle metabolism are dependent on the duration and severity of hypoxic exposure, though factors which dictate the nature of the metabolic response to hypoxia are poorly understood.
Burgess, Sarah L., Horscroft, James A., Hu, Yaqi, Murray, Andrew J.   +3 more
core   +11 more sources

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation. [PDF]

, 2019
Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens.
Amarnath, Venkataraman, Bridges, Christy C, Davies, Sean, Dikalov, Sergey, Dikalova, Anna, Mayorov, Vladimir, Moore, Christy S, Panov, Alexander V, Uchakin, Peter, Uzhachenko, Roman, Zackert, Bill   +10 more
core  

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]

, 2013
Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F., Lowes, D. A., Murphy, M. P., Webster, N. R.   +3 more
core   +1 more source

Nitric oxide and mitochondrial respiration

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999
Nitric oxide (NO) and its derivative peroxynitrite (ONOO-) inhibit mitochondrial respiration by distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome oxidase in competition with oxygen, and this inhibition is fully reversible when NO is removed.
openaire   +2 more sources