Phosphoenolpyruvate carboxylase dentified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism [PDF]
, 2014 Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in thePlasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10Δpepc),
A Chokkathukalam +70 more
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Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]
, 2017 Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio +7 more
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The quantum mitochondrion and optimal health [PDF]
Biochemical Society Transactions, 2016 A sufficiently complex set of molecules, if subject to perturbation, will self-organize and show emergent behaviour. If such a system can take on information it will become subject to natural selection. This could explain how self-replicating molecules evolved into life and how intelligence arose.
Geoffrey Guy +2 more
openaire +2 more sources
Unsupervised segmentation of mitochondria using model-based spectral clustering [PDF]
, 2013 Segmentation of mitochondria in microscopic images represents a significant challenge that is motivated by the wide morphological and structural variations that are characteristic for this category of membrane enclosed sub cellular organelles. To address
Dietlmeier, Julia +2 more
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A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production [PDF]
, 2013 A high membrane potential across the mitochondrial inner membrane leads to the production of the reactive oxygen species (ROS) implicated in aging and age-related diseases.
Affourtit +35 more
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The return of the mitochondrion [PDF]
The Biochemist, 2005 For a fresh-faced (well, apart from the beard) PhD graduate in 1989, mitochondrial bioenergetics might have seemed a strange choice of research path. Flushed with the general acceptance of the chemiosmotic theory, many felt that the area had passed its heyday. With the publication of its ‘bible’ (Bioenergetics, the definitive textbook by David Nicholls)
openaire +1 more source
Was the Mitochondrion Necessary to Start Eukaryogenesis? [PDF]
Trends in Microbiology, 2019 Arguments based on cell energetics favour the view that a mitochondrion capable of oxidative phosphorylation was a prerequisite for the evolution of other features of the eukaryotic cell, including increased volume, genome size and, eventually, phagotrophy.
Hampl, Vladimír +2 more
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Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. [PDF]
, 2012 PurposePostnatal lead exposure produces rod-selective and Bax-mediated apoptosis, decreased scotopic electroretinograms (ERGs), and scotopic and mesopic vision deficits in humans and/or experimental animals.
Ellisman, Mark H +5 more
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Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore [PDF]
, 2012 Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and ...
Andrew G. Cairns +46 more
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Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure [PDF]
, 2018 Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects.
Benaim, Gustavo +4 more
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