Results 31 to 40 of about 10,797 (208)

The theory of oxidative stress as a direct cause of cell aging

Medisur, 2018
The loss of functional capacities, aging and death are inherent to all living matter due to metabolism and other factors causing the formation of substances which damage irreversibly cell structure components.
Milagros Lisset León Regal, Raúl Cedeño Morales, Rodolfo Javier Rivero Morey, Jeisy Rivero Morey, Diana Laura García Pérez, Leissay Bordón González   +5 more
doaj   +2 more sources

Efectos del estrés oxidativo en la retina [PDF]

, 2019
La absorción de la luz por las células de la retina produce reacciones fotoquímicas que dan lugar a las especies reactivas de oxígeno y a radicales libres que crean un nivel de estrés oxidativo alto. Se planteó este trabajo de revisión bibliográfica para
López Tejedor, Agustín
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TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, Volume 293, Issue 6, Page 1771-1784, March 2026.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Bases moleculares de la neuropatía óptica hereditaria de leber [PDF]

, 2016
La neuropatía óptica hereditaria de Leber (NOHL) se encuentra entre las neuropatías heredadas de forma materna más comunes y fue la primera enfermedad mitocondrial descrita, causando una pérdida de visión bilateral con mayor prevalencia en los varones ...
Márquez Quidiello, María Teresa
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PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, Volume 20, Issue 2, Page 447-463, February 2026.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Estudio de las variantes genéticas mitocondriales en el sistema de detoxidificación celular: papel en la artrosis [PDF]

, 2016
[Resumen] Objetivo: Investigar las interacciones entre los haplogrupos mitocondriales y diferentes polimorfismos de genes que intervienen en la detoxificación celular en la prevalencia de la artrosis de cadera.
Hermida Nogueira, Lidia
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, Volume 20, Issue 2, Page 307-330, February 2026.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Modulación de la señal de calcio y los receptores de IP3 en neuronas de hipocampo envejecidas in vitro y tratadas con oligómeros del péptido amiloide [PDF]

, 2019
El envejecimiento y las enfermedades neurodegenerativas asociadas al mismo son actualmente un reto social, debido a su incipiente aumento en los países desarrollados.
López Vázquez, Sara
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, Volume 20, Issue 2, Page 428-446, February 2026.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Nuevas terapias para la neuropatía óptica hereditaria de Leber [PDF]

, 2016
La neuropatía óptica hereditaria de Leber es una enfermedad rara ligada al ADN mitocondrial, de manera que es transmitida verticalmente de madres a hijos.
Lora Domínguez, Paula Carla
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