Results 131 to 140 of about 16,238 (247)
Loss of Mfn1 but not Mfn2 enhances adipogenesis.
PLoS ONEObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or ...
Jake P Mann +15 more
doaj +1 more source
Autophagy in ischemic aged livers
Liver Research, 2018 Ischemia/reperfusion (I/R) injury inevitably occurs during liver resection and transplantation. Elderly patients poorly recover from these surgeries.
Choonghee Lee, Jae-Sung Kim
doaj +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu +11 more
wiley +1 more source
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
Nature Communications, 2019 Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms ...
Yu-Jie Li +15 more
doaj +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu +7 more
wiley +1 more source
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.
PLoS ONE, 2011 PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy ...
Aleksandar Rakovic +6 more
doaj +1 more source
Charcot-Marie-Tooth neuropathy type 2A: novel mutations in the mitofusin 2 gene (
BMC Medical Genetics, 2006 Background Charcot-Marie-Tooth neuropathies are a group of genetically heterogeneous diseases of the peripheral nervous system. Mutations in the MFN2 gene have been reported as the primary cause of Charcot-Marie-Tooth disease type 2A.
Haas Gerhard +6 more
doaj +1 more source
Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways [PDF]
, 2016 Cachexia represents one of the primary complications of colorectal cancer due to its effects on depletion of muscle and fat. Evidence suggests that chemotherapeutic regimens, such as Folfiri, contribute to cachexia-related symptoms.
Barreto, Rafael +5 more
core +3 more sources
Mitofusin 2 keeps the respiratory chain on Q [PDF]
Journal of Cell Biology, 2015 ![Figure][1] Many mitochondria (green) show reduced membrane potential (indicated by the potentiometric reporter TMRM, red) in fibroblasts lacking MFN2. [Mourier et al.][2] reveal that the mitochondrial fusion protein Mitofusin 2 (MFN2) is required to maintain production of the ...
openaire +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos +12 more
wiley +1 more source