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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown.
Luca Scorrano, Olga Martins de Brito
exaly +2 more sources
Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans ...
Takumi Koshiba +2 more
exaly +1 more source
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E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
Molecular Cell, 2023Mafalda Escobar-Henriques +2 more
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Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy
EMBO Reports, 2018Thomas Rival +2 more
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Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin
Cell Metabolism, 2019Meng-ju Wu, Silpa Gampala, Yu-Syuan Chen
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