Results 131 to 140 of about 17,663,424 (207)
Overexpression of mitofusin 2 in the diabetic heart; pathological or cardioprotective remodelling?
, 2015 Background: Mitochondrial dysfunction is an established hallmark of diabetic cardiomyopathy (DCM). Mitofusin 2 (Mfn2) is widely believed to function as a molecular tether, binding mitochondria to the sarcoplasmic reticulum (SR) to form specialised Ca2 ...
Kitmitto, Ashraf +6 more
core +1 more source
Acylglycerol Kinase Inhibition Restores Mitophagy and Alleviates Alzheimer's Disease Pathology
MedComm, Volume 7, Issue 7, July 2026.AGK (acylglycerol kinase) is abnormally upregulated in AD patients and mouse models. By stabilizing the TOM–TIM complex, this excess AGK facilitates PINK1 translocation to the IMM and prevents its OMM accumulation, leading to mitophagy impairment.
Wensheng Li +12 more
wiley +1 more source
The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song +6 more
wiley +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed +21 more
wiley +1 more source
Metabolic Kinases as Regulators of Inter‐Organelle Communication in Aging and Age‐Related Diseases
Aging Cell, Volume 25, Issue 7, July 2026.Metabolic kinases integrate cellular energy, nutrient, and stress signals to regulate inter‐organelle coordination during aging. In young or healthy cells, coordinated communication among mitochondria, the endoplasmic reticulum, lysosomes, peroxisomes, and the Golgi apparatus supports calcium handling, lipid metabolism, mitochondrial dynamics ...
Md Riad Chowdhury +2 more
wiley +1 more source
Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis
, 2007 An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for heart failure. Here, we have provided several lines of evidence to demonstrate that mitofusin-2 (Mfn-2; also called hyperplasia suppressor gene), a member ...
Shen, Tao +17 more
core +1 more source
, 2012 The induction of “in vitro” capacitation (IVC) and subsequent, progesterone-induced “in vitro” acrosome reaction (IVAR) was concomitant with an increase in actin polymerization, also showing an increase in actin presence at the apical area of the ...
J. M. Fernández Novell +5 more
core +1 more source
The Role of Mammalian Mitofusin-2 (Mfn-2) in Lipid Metabolism [PDF]
, 2017 The architecture of mitochondria is closely associated with numerous functions for cell signaling, growth and senescence. The overall phenomenon of mitochondrial dynamics, which include fusion and fission events, characterizes the fundamental mechanism ...
Ambilwade, Prashant of 1984-
core
Zebrafish mitofusin-2 knockdown: a new model for CMT2A neuropathy?
, 2009 Mitofusin 2 (MFN2) is a large dynamin-like GTPase protein, located in the outer membrane of mitochondria and at the surface of the endoplasmic reticulum.
VETTORI, ANDREA +7 more
core