Results 171 to 180 of about 17,663,424 (207)

Autophagy and proliferation are dysregulated in Charcot-Marie-Tooth disease type 2A cells harboring MFN2 (mitofusin 2) mutation. [PDF]

Autophagy Rep, 2022
Zanfardino P, Petruzzella V.
europepmc   +1 more source

Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2. [PDF]

Stem Cell Res Ther
Xiang Y, Li Z, He X, Chu X, Gao C, Guo J, Luan Y, Yang K, Zhang D.   +8 more
europepmc   +1 more source

The role of mitofusin 2 in regulating endothelial cell senescence: Implications for vascular aging. [PDF]

iScience
Li J, Yang Z, Song H, Yang L, Na K, Mei Z, Zhang S, Liu J, Xu K, Yan C, Wang X.   +10 more
europepmc   +1 more source

Corrigendum to "Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species". [PDF]

Oxid Med Cell Longev
europepmc   +1 more source

Mitofusin 2 Variant Presenting With a Phenotype of Multiple System Atrophy of Cerebellar Subtype. [PDF]

Neurol Genet
Elbert A, Dixon K, Shen Y, Hamilton S, Boerkoel CF, Jones SJ, Kanungo AK.   +6 more
europepmc   +1 more source

Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2

Pharmacological Research, 2018
The endoplasmic reticulum (ER) and the mitochondrial network are two highly interconnected cellular structures. By proteinaceous tethers, specialized membrane domains of the ER are tightly associated with the outer membrane of mitochondria, allowing the assembly of signaling platforms where different cell functions take place or are modulated, such as ...
Riccardo Filadi, Elisa Greotti, Paola Pizzo   +2 more
exaly   +5 more sources

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Mitofusin-2 in cancer: Friend or foe?

Archives of Biochemistry and Biophysics, 2022
Cancer is a category of disorders characterized by excessive cell proliferation with the ability to infiltrate or disseminate to other organs of the body. Mitochondrial dysfunction, as one of the most prominent hallmarks of cancer cells, has been related to the onset and development of various cancers.
Pushpamala, Ramaiah, Indrajit, Patra, Anum, Abbas, Ali Abdulhussain, Fadhil, Mohammad, Abohassan, Zahraa Haleem, Al-Qaim, Noora Mohammed, Hameed, Moaed Emran, Al-Gazally, Saif Sabbar, Kemil Almotlaq, Yasser Fakri, Mustafa, Yavar, Shiravand   +10 more
openaire   +2 more sources

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

Science, 2004
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans ...
Takumi Koshiba, Jens T Kaiser, Hsiuchen Chen   +2 more
exaly   +1 more source

Mitofusin-2 is a novel direct target of p53

Biochemical and Biophysical Research Communications, 2010
The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang, Xiaofei, Cheng, Jianju, Lu, Jianfeng, Wei, Guanghou, Fu, Feng, Zhu, Changku, Jia, Lin, Zhou, Haiyang, Xie, Shusen, Zheng   +9 more
openaire   +2 more sources

Role of mitofusin 2 in cardiovascular oxidative injury

Journal of Molecular Medicine, 2010
Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
openaire   +2 more sources