Results 201 to 210 of about 15,895 (241)

Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2.

J Cell Sci
Narendradev ND, Ravindran R, Jain P, Chaudhary S, Velikkakath AKG, Sudharman A, Janardhanan A, Nag TC, Yadav SC, Srinivasula SM.   +9 more
europepmc   +1 more source

Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2. [PDF]

J Physiol Sci
Olaniyi KS, Areloegbe SE.
europepmc   +1 more source

Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2. [PDF]

iScience
Yan CY, Ye Y, Mu HL, Wu T, Huang WS, Wu YP, Sun WY, Liang L, Duan WJ, Ouyang SH, Huang RT, Wang R, Sun XX, Kurihara H, Li YF, He RR.   +15 more
europepmc   +1 more source

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

Nature, 2008
Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
Luca Scorrano
exaly   +5 more sources

Mitofusin-2 in cancer: Friend or foe?

Archives of Biochemistry and Biophysics, 2022
Cancer is a category of disorders characterized by excessive cell proliferation with the ability to infiltrate or disseminate to other organs of the body. Mitochondrial dysfunction, as one of the most prominent hallmarks of cancer cells, has been related to the onset and development of various cancers.
Pushpamala, Ramaiah, Indrajit, Patra, Anum, Abbas, Ali Abdulhussain, Fadhil, Mohammad, Abohassan, Zahraa Haleem, Al-Qaim, Noora Mohammed, Hameed, Moaed Emran, Al-Gazally, Saif Sabbar, Kemil Almotlaq, Yasser Fakri, Mustafa, Yavar, Shiravand   +10 more
openaire   +2 more sources

Mitofusin-2 is a novel direct target of p53

Biochemical and Biophysical Research Communications, 2010
The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang, Xiaofei, Cheng, Jianju, Lu, Jianfeng, Wei, Guanghou, Fu, Feng, Zhu, Changku, Jia, Lin, Zhou, Haiyang, Xie, Shusen, Zheng   +9 more
openaire   +2 more sources

Role of mitofusin 2 in cardiovascular oxidative injury

Journal of Molecular Medicine, 2010
Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
openaire   +2 more sources

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance The privileged interrelationship between mitochondria and the endoplasmic reticulum (ER) plays a key role in a variety of physiological functions, from lipid metabolism to Ca 2+ signalling, and its modulation influences apoptotic susceptibility, mitophagy, and ...
Riccardo Filadi, Elisa Greotti, Alberto Luini   +2 more
exaly   +4 more sources

Relationship between mitofusin 2 and cancer

2019
Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra, V. Innao, A. G. Allegra, C. Musolino   +3 more
openaire   +3 more sources