Results 231 to 240 of about 16,238 (247)

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

Science Signaling, 2009
A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa, Hiroyuki, Oshiumi, Makoto, Takeda, Naotada, Ishihara, Yusuke, Yanagi, Tsukasa, Seya, Shun-ichiro, Kawabata, Takumi, Koshiba   +7 more
openaire   +2 more sources

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

Nature, 2008
Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
de Brito OM, SCORRANO, LUCA
openaire   +4 more sources

Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2

The International Journal of Biochemistry & Cell Biology, 2017
Doxorubicin (DOX) is an anti-tumor agent that is widely used in clinical setting for cancer treatment. The application of the DOX, however, is limited by its cardiac toxicity which can induce heart failure through an undefined mechanism. Mitofusin 2 (Mfn2) is a mitochondrial GTPase fusion protein that is located on the outer membrane of mitochondria ...
Han, Tang, Aibin, Tao, Jia, Song, Qian, Liu, Hao, Wang, Tao, Rui   +5 more
openaire   +2 more sources

Mitofusin-2: Functional switch between mitochondrial function and neurodegeneration

Mitochondrion, 2023
Mitochondria are highly dynamic organelles known to play role in the regulation of several cellular biological processes. However, their dynamics such as number, shape, and biological functions are regulated by mitochondrial fusion and fission process.
Prakash G. Kulkarni, Vaibhavi M Mohire, Pooja K Bhaisa, Mrudula M Joshi, Chitranshi M Puranik, Pranjal P Waghmare, Tanushree Banerjee   +6 more
openaire   +2 more sources

Role of mitofusin 2 in cardiovascular oxidative injury

Journal of Molecular Medicine, 2010
Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
openaire   +2 more sources

Relationship between mitofusin 2 and cancer

2019
Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra, V. Innao, A. G. Allegra, C. Musolino   +3 more
openaire   +3 more sources

Mitofusin-2 is a novel direct target of p53

Biochemical and Biophysical Research Communications, 2010
The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang, Xiaofei, Cheng, Jianju, Lu, Jianfeng, Wei, Guanghou, Fu, Feng, Zhu, Changku, Jia, Lin, Zhou, Haiyang, Xie, Shusen, Zheng   +9 more
openaire   +2 more sources

miR-106a promotes cardiac hypertrophy by targeting mitofusin 2

Journal of Molecular and Cellular Cardiology, 2016
Pathological cardiac hypertrophy is a main factor leading to heart failure and associated sudden death. Improved understanding of the underlying molecular mechanisms should aid better treatment of the disease. This study aimed to test our hypothesis that a microRNA miR-106a played an important role in the development of cardiac hypertrophy through ...
Xiaoxiang, Guan, Lu, Wang, Zhenhong, Liu, Xiaofei, Guo, Yuan, Jiang, Ying, Lu, Yanli, Peng, Tianhua, Liu, Baofeng, Yang, Hongli, Shan, Yong, Zhang, Chaoqian, Xu   +11 more
openaire   +2 more sources

A human mitofusin 2 mutation causes mitophagic cardiomyopathy

2022
Abstract Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is ~20x over-represented in clinical cardiomyopathy, whereas this specific mutation ...
Antonietta Franco, Jiajia Li, Daniel P. Kelly, Ray E. Hershberger, Ali J. Marian, Renate M. Lewis, Moshi Song, Xiawei Dang, Alina D. Schmidt, Mary E. Mathyer, Cristina de Guzman Strong, Gerald W. Dorn   +11 more
openaire   +1 more source

G331(P) Sibling-pair with Mitofusin 2 mutation

Archives of Disease in Childhood, 2014
Case details We report a sibling pair who presented with mixed upper and lower motor neuron signs with a rare mitochondrial fusion protein disorder. Case 1: An 18 month old boy child, born at full-term after an uneventful delivery, presented with motor delay and hypotonia. At 3 months of age he was investigated for an apnoeic and floppy episode.
S. Jain, T. Willis, E. Wassmer, S. Agrawal   +3 more
openaire   +1 more source