Results 211 to 220 of about 15,895 (241)

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

Science Signaling, 2009
A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa, Hiroyuki, Oshiumi, Makoto, Takeda, Naotada, Ishihara, Yusuke, Yanagi, Tsukasa, Seya, Shun-ichiro, Kawabata, Takumi, Koshiba   +7 more
openaire   +2 more sources

Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2

Pharmacological Research, 2018
The endoplasmic reticulum (ER) and the mitochondrial network are two highly interconnected cellular structures. By proteinaceous tethers, specialized membrane domains of the ER are tightly associated with the outer membrane of mitochondria, allowing the assembly of signaling platforms where different cell functions take place or are modulated, such as ...
Riccardo Filadi, Elisa Greotti, Paola Pizzo   +2 more
exaly   +4 more sources

Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2

The International Journal of Biochemistry & Cell Biology, 2017
Doxorubicin (DOX) is an anti-tumor agent that is widely used in clinical setting for cancer treatment. The application of the DOX, however, is limited by its cardiac toxicity which can induce heart failure through an undefined mechanism. Mitofusin 2 (Mfn2) is a mitochondrial GTPase fusion protein that is located on the outer membrane of mitochondria ...
Han, Tang, Aibin, Tao, Jia, Song, Qian, Liu, Hao, Wang, Tao, Rui   +5 more
openaire   +2 more sources

Evaluation of the role of mitofusin‐1 and mitofusin‐2 in periodontal disease

Journal of Periodontology, 2023
AbstractBackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria‐endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation.
Ömer Alperen Kırmızıgül, Arife Sabanci, Faruk Dişli, Sedat Yıldız, Michael R. Milward, Kübra Aral   +5 more
openaire   +2 more sources

Altered expression of mitofusin 2 in penile tissues of diabetic rats

Andrologia, 2013
Diabetic erectile dysfunction (ED) is a common complication in diabetes mellitus, and the efficacy of first-line therapies is not satisfactory. Recent studies revealed that corporal apoptosis was responsible for the nonresponsiveness of severe ED to phosphodiesterase type 5 inhibitors. Mitofusin 2 (Mfn2) is a versatile protein, regulating mitochondrial
J, Yang, T, Wang, Y, Zhang, R, Li, S, Wang, H, Xu, J, Liu, Z, Ye   +7 more
openaire   +2 more sources

Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2

Annals of Neurology, 2006
AbstractObjectiveCharcot‐Marie‐Tooth (CMT) neuropathy with visual impairment due to optic atrophy has been designated as hereditary motor and sensory neuropathy type VI (HMSN VI). Reports of affected families have indicated autosomal dominant and recessive forms, but the genetic cause of this disease has remained elusive.MethodsHere, we describe six ...
Züchner, Stephan, De Jonghe, Peter, Jordanova, Albena, Claeys, Kristl G., Guergueltcheva, Velina, Cherninkova, Sylvia, Hamilton, Steven R., van Stavern, Greg, Krajewski, Karen M., Stajich, Jeffery, Tournev, Ivajlo, Verhoeven, Kristien, Langerhorst, Christine T., de Visser, Marianne, Baas, Frank, Bird, Thomas, Timmerman, Vincent, Shy, Michael, Vance, Jeffery M.   +18 more
openaire   +4 more sources

IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy

Cardiovascular Research
Abstract Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is ...
Matthew Guberman, Rimpy Dhingra, Jenna Cross, Victoria Margulets, Hongying Gang, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum   +6 more
openaire   +2 more sources

Resveratrol stimulates mitochondrial fusion by a mechanism requiring mitofusin-2

Biochemical and Biophysical Research Communications, 2017
Resveratrol (RES) is a plant-derived stilbene associated with a wide range of health benefits. Mitochondria are a key downstream target of RES, and in some cell types RES promotes mitochondrial biogenesis, altered cellular redox status, and a shift toward oxidative metabolism. Mitochondria exist as a dynamic network that continually remodels via fusion
Ellen L, Robb, Fereshteh, Moradi, Lucas A, Maddalena, Andrew J F, Valente, Joao, Fonseca, Jeffrey A, Stuart   +5 more
openaire   +2 more sources

Mitofusin 2 as a Driver That Controls Energy Metabolism and Insulin Signaling

Antioxidants & Redox Signaling, 2015
Significance: Mitochondrial dynamics is a complex process that impacts on mitochondrial biology. Recent Advances: Recent evidence indicates that proteins participating in mitochondrial ...
Antonio, Zorzano, María Isabel, Hernández-Alvarez, David, Sebastián, Juan Pablo, Muñoz   +3 more
openaire   +2 more sources

Overexpression of mitofusin 2 inhibits reactive astrogliosis proliferation in vitro

Neuroscience Letters, 2014
Astrocytes become activated in response to central nervous system (CNS) injury, and excessive astrogliosis is considered an impediment to axonal regeneration by forming glial scar. Mitofusin 2 (Mfn2), a key protein in mitochondrial network, has been reported to negatively regulate cell proliferation.
Tao, Liu, Chen-chen, Xue, Yu-long, Shi, Xiang-jun, Bai, Zhan-fei, Li, Cheng-la, Yi   +5 more
openaire   +2 more sources