Results 11 to 20 of about 673,597 (383)

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. [PDF]

PLoS ONE, 2017
The ovary is the main regulator of female fertility. Granulosa cell dysfunction may be involved in various reproductive endocrine disorders. Here we investigated the effect of insulin resistance on the metabolism and function of ovarian granulosa cells ...
Linghui Kong, Qien Wang, Jiewen Jin, Zou Xiang, Taoyu Chen, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang   +8 more
doaj   +1 more source

Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood

Acta Dermato-Venereologica, 2022
Pyogenic granuloma is one of the most common vascular tumours. The cause of pyogenic granuloma was previously thought to be an inflammatory reaction with consecutive stimulation of endothelial cell proliferation.
Katharina Strobel, Katja Maurus, Henning Hamm, Sabine Roth, Matthias Goebeler, Andreas Rosenwald, Marion Wobser   +6 more
doaj   +1 more source

Effect of MST1 on Invasion and Migration of Colon Cancer through Mitogen-Activated Protein Kinase/Extracellular SignalRegulated Kinase Signal Pathway [PDF]

, 2021
To explore the effect of mammalian STE20 like protein kinase 1 on colon cancer invasion and metastasis through mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.
Divya, G.Ratnakumari, V.Raju
core   +2 more sources

Mitogen-activated protein kinase cascades in plant signaling.

Journal of Integrative Plant Biology, 2022
Mitogen-activated protein kinase (MAPK) cascades are key signaling modules downstream of receptors/sensors that perceive either endogenously produced stimuli such as peptide ligands and damage-associated molecular patterns (DAMPs) or exogenously ...
Mengmeng Zhang, Shuqun Zhang
semanticscholar   +1 more source

Kinase Activity Profiling of Gram-Negative Pneumonia [PDF]

, 2011
Pneumonia is a severe disease with high morbidity and mortality. A major causative pathogen is the Gram-negative bacterium Klebsiella (K.) pneumoniae. Kinases play an integral role in the transduction of intracellular signaling cascades and regulate a ...
Diks, Sander H., Hoogendijk, Arie J., Peppelenbosch, Maikel P., van der Poll, Tom, Wieland, Catharina W.   +4 more
core   +5 more sources

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

Journal of Biological Chemistry, 1998
The compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements
M. Favata, K. Horiuchi, E. Manos, A. J. Daulerio, Deborah A. Stradley, W. Feeser, Drew E. Van Dyk, W. Pitts, R. Earl, F. Hobbs, R. Copeland, R. Magolda, P. Scherle, J. Trzăskos   +13 more
semanticscholar   +1 more source

Mitogen-Activated Protein Kinase Pathway in Amyotrophic Lateral Sclerosis

Biomedicines, 2021
Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease. Multiple genetic and non-genetic risk factors are associated with disease pathogenesis, and several cellular processes, including protein homeostasis, RNA metabolism, vesicle ...
TG Sahana, Ke Zhang
doaj   +1 more source

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. [PDF]

PLoS ONE, 2009
Mechanical ventilation, a fundamental therapy for acute lung injury, worsens pulmonary vascular permeability by exacting mechanical stress on various components of the respiratory system causing ventilator associated lung injury.
Mahendra Damarla, Emile Hasan, Adel Boueiz, Anne Le, Hyun Hae Pae, Calypso Montouchet, Todd Kolb, Tiffany Simms, Allen Myers, Usamah S Kayyali, Matthias Gaestel, Xinqi Peng, Sekhar P Reddy, Rachel Damico, Paul M Hassoun   +14 more
doaj   +1 more source