Results 11 to 20 of about 520,457 (360)

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. [PDF]

PLoS ONE, 2009
Mechanical ventilation, a fundamental therapy for acute lung injury, worsens pulmonary vascular permeability by exacting mechanical stress on various components of the respiratory system causing ventilator associated lung injury.
Mahendra Damarla, Emile Hasan, Adel Boueiz, Anne Le, Hyun Hae Pae, Calypso Montouchet, Todd Kolb, Tiffany Simms, Allen Myers, Usamah S Kayyali, Matthias Gaestel, Xinqi Peng, Sekhar P Reddy, Rachel Damico, Paul M Hassoun   +14 more
doaj   +1 more source

Mitogen-Activated Protein Kinase Pathway in Amyotrophic Lateral Sclerosis

Biomedicines, 2021
Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease. Multiple genetic and non-genetic risk factors are associated with disease pathogenesis, and several cellular processes, including protein homeostasis, RNA metabolism, vesicle ...
TG Sahana, Ke Zhang
doaj   +1 more source

PREDICTION OF 3D STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 USING ALPHAFOLD 2 AND SIMULATION OF ITS INTERACTION WITH MITOGEN-ACTIVATED PROTEIN KINASE 6 IN ARABIDOPSIS THALIANA [PDF]

Journal of Plant Development
Arabidopsis thaliana mitogen-activated protein kinase (MPK or MAPK) signaling network plays significant roles in various cellular processes. The three-dimensional structure of mitogen-activated protein kinase kinase 2 (MKK2), an upstream kinase in the ...
Sameer KHAN, Tim XING
doaj   +1 more source

p38 mitogen‐activated protein kinase: Functions and targeted therapy in diseases

MedComm – Oncology, 2023
P38 mitogen‐activated protein kinase (p38MAPK) is a multifunctional protein kinase that plays an important role in human normal physiological activities and a variety of major diseases, and its signaling pathway affects a variety of regulatory factors in
Qinwen Zheng, Shutong Li, Aoxue Wang, Man Zhe, Panpan Yang, Yongya Wu, Min Zhao, Yumeng Zhu, Yi Luo, Guan Wang, Liang Ouyang   +10 more
doaj   +1 more source

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways

Journal of Ginseng Research, 2016
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin, Wei Yang, Dongxu Feng, Xinwen Wang, Muyao Qi, Tianxin Du, Hongzhi Sun, Shufang Wu   +7 more
doaj   +1 more source

Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer

EMBO Molecular Medicine, 2021
In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible organization.
Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc, Yana Ruchiy, Thomas Sell, Soulafa Mamlouk, Roberto Arsie, Tzu‐Ting Wei, Kathleen Klotz‐Noack, Roland F Schwarz, Birgit Sawitzki, Carsten Kamphues, Dieter Beule, Markus Landthaler, Christine Sers, David Horst, Nils Blüthgen, Markus Morkel   +22 more
doaj   +1 more source

Genome-wide identification and transcriptional expression analysis of mitogen-activated protein kinase and mitogen-activated protein kinase kinase genes in Capsicum annuum

Frontiers in Plant Science, 2015
The tripartite mitogen-activated protein kinase (MAPK) signaling cascades have been implicated in plant growth, development, and environment adaptation, but a comprehensive understanding of MAPK signaling at genome-wide level is limited in Capsicum ...
Shuilin eHe, zhiqin eliu, zhiqin eliu, lanping eshi, lanping eshi, yanyan eliu, yanyan eliu, lei eshen, lei eshen, sheng eyang, sheng eyang, jinsen ecai, qian etang, qian etang, huanxin eyu, huanxin eyu, rongzhang ewang, rongzhang ewang, jiayu ewen, jiayu ewen, youquan elin, youquan elin, jiong ehu, jiong ehu, cailing eliu, cailing eliu, shaoliang emou   +26 more
doaj   +1 more source

Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion. [PDF]

PLoS ONE, 2018
OBJECTIVES:To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of ...
Leticia Serrano-Oviedo, Marta Ortega-Muelas, Jesús García-Cano, María Ll Valero, Francisco J Cimas, Raquel Pascual-Serra, Diego M Fernandez-Aroca, Olga Roche, María J Ruiz-Hidalgo, Borja Belandia, José M Giménez-Bachs, Antonio S Salinas, Ricardo Sanchez-Prieto   +12 more
doaj   +1 more source

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)

Journal of Biological Chemistry, 1995
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism.
J. Raingeaud, Shashi Gupta, J. S. Rogers, M. Dickens, Jiahuai Han, R. Ulevitch, R. Davis   +6 more
semanticscholar   +1 more source