ARABIDOPSIS ATMKK1 KNOCKOUT MUTANT FLOWERS UNDER SHORT DAY CONDITIONS [PDF]
Journal of Plant DevelopmentThere are a variety of conditions that regulate flowering time in Arabidopsis, but there are no reported instances mitogen-activated protein kinase pathways playing a decisive role in flowering time.
Chad CONROY, Khadijah M. NIZAM, Tim XING
doaj +1 more source
Mitogen-activated protein kinase cascades in Vitis vinifera
Frontiers in Plant Science, 2015 Protein phosphorylation is one of the most important mechanisms to control cellular functions in response to external and endogenous signals. Mitogen-activated protein kinases (MAPK) are universal signaling molecules in eukaryotes that mediate the ...
Birsen eÇAKIR, Ozan eKılıçkaya
doaj +1 more source
MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng +9 more
doaj +1 more source
Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. [PDF]
PLoS ONE, 2016 Abnormal survival of retinal pigment epithelium (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR), a sight-threatening disease.
Xiaodong Chen +6 more
doaj +1 more source
Mitogen Activated Protein kinase signal transduction pathways in the prostate
Cell Communication and Signaling, 2004 The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty +3 more
doaj +1 more source
Journal of Pharmacological Sciences, 2012 Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family.
Masanori Yoshizumi +6 more
doaj +1 more source
Mitogen-activated protein kinase kinase 7 in inflammatory, cancer, and neurological diseases
Frontiers in Cell and Developmental Biology, 2022 Stress-activated mitogen-activated protein kinase kinase 7 (MKK7) is a member of the dual-specificity mitogen-activated protein kinase family. In the human body, MKK7 controls essential physiological processes, including but not limited to proliferation ...
Amada D. Caliz +6 more
doaj +1 more source
P38 mitogen-activated protein kinase and Parkinson’s disease
Translational Neuroscience, 2018 Parkinson’s disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson’s disease are not fully understood, considerable evidence suggests that neuro-inflammation ...
He Jianying +4 more
doaj +1 more source
MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization. [PDF]
PLoS ONE, 2012 BACKGROUND: The response of the postnatal heart to growth and stress stimuli includes activation of a network of signal transduction cascades, including the stress activated protein kinases such as p38 mitogen-activated protein kinase (MAPK), c-Jun NH2 ...
Hamid el Azzouzi +5 more
doaj +1 more source
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4. [PDF]
PLoS ONE, 2013 Prostate cancer (PCa) is the second highest cause of cancer death in United States males. If the metastatic movement of PCa cells could be inhibited, then mortality from PCa could be greatly reduced. Mitogen-activated protein kinase kinase 4 (MAP2K4) has
Sankar N Krishna +6 more
doaj +1 more source