Results 21 to 30 of about 458,508 (146)

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

Endocrine reviews, 2001
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and ...
G. Pearson, Fred L Robinson, T. Gibson, Bing-e Xu, M. Karandikar, K. Berman, M. Cobb   +6 more
semanticscholar   +1 more source

Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. [PDF]

, 2015
BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens.
Aguirre, Alejandro, Cheung, Kong, Drexler, Anna, Eigenheer, Richard, Giulivi, Cecilia, Glennon, Elizabeth KK, Klyver, John M, Lewis, Edwin E, Luckhart, Shirley, Napoli, Eleonora, Pakpour, Nazzy, Phinney, Brett S, Surachetpong, Win, Wang, Bo   +13 more
core   +1 more source

Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]

, 2007
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L, Firestein, Gary S, Hammaker, Deepa R, Inoue, Tomoyuki   +3 more
core   +2 more sources

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines [PDF]

, 2008
Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of
Ahmad, Andrew K. Marshall, Angela Clerk, Atkins, Bieker, Bilanges, Bogoyevitch, Boon, Chen, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Cook, Cullingford, Dang, Davies, Dorn, El Li Tham, Favata, Feinberg, Fisch, Ghaleb, Haldar, Hamik, Harrison, Inuzuka, Iwaki, Kaczynski, Kawai-Kowase, Kemp, Kennedy, Kojima, Kyriakis, Lavallée, Leung, Liu, Lomberk, Markou, Matthew J. Butler, Mody, Moriguchi, Ornatsky, Peter H. Sugden, Pham, Pham, Scohy, Sohn, Sugden, Sun, Suske, Suzuki, Timothy E. Cullingford, Uchida, van Thienen, van Vliet, Wani, Yang   +61 more
core   +2 more sources

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Proceedings of the National Academy of Sciences of the United States of America, 1996
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved series of three protein kinases implicated in diverse biological processes. Here we demonstrate that the cascade arrangement has unexpected consequences for the dynamics of MAPK ...
Chi-Ying F. Huang, J. Ferrell
semanticscholar   +1 more source

Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]

, 2015
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine, Gray, Nathanael S, Hellman, Judith, Khakpour, Samira, Prakash, Arun, Sundar, Shirin, Tran, Alphonso, Wang, Jinhua, Wilhelmsen, Kevin, Xu, Fengyun   +9 more
core   +1 more source

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Background The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk.
M. Seldin, Yonghong Meng, Hongxiu Qi, Weifei Zhu, Zeneng Wang, S. Hazen, A. Lusis, D. Shih   +7 more
semanticscholar   +1 more source

Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling

Frontiers in Plant Science, 2018
Mitogen-activated protein kinase (MAPK) modules play key roles in the transduction of environmental and developmental signals through phosphorylation of downstream signaling targets, including other kinases, enzymes, cytoskeletal proteins or ...
P. Jagodzik, Małgorzata Tajdel-Zielińska, A. Cieśla, Małgorzata Marczak, A. Ludwików   +4 more
semanticscholar   +1 more source

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Regulation of Cell Motility by Mitogen-activated Protein Kinase

Journal of Cell Biology, 1997
Cell interaction with adhesive proteins or growth factors in the extracellular matrix initiates Ras/ mitogen-activated protein (MAP) kinase signaling.
R. Klemke, S. Cai, A. Giannini, P. Gallagher, P. de Lanerolle, D. Cheresh   +5 more
semanticscholar   +1 more source