In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway. [PDF]
, 2013 BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3.
Dholakia, S +6 more
core +2 more sources
Dynamic Studies of Scaffold-dependent Mating Pathway in Yeast [PDF]
, 2006 The mating pathway in \emph{Saccharomyces cerevisiae} is one of the best understood signal transduction pathways in eukaryotes. It transmits the mating signal from plasma membrane into the nucleus through the G-protein coupled receptor and the mitogen ...
Ouyang, Qi +4 more
core +3 more sources
p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. [PDF]
, 2014 In CNS lesions, "reactive astrocytes" form a prominent cellular response. However, the nature of this astrocyte immune activity is not well understood.
Chechneva, OV +5 more
core +1 more source
Mediators of Inflammation, 2014 Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many ...
Yanyan Yang +7 more
semanticscholar +1 more source
Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism [PDF]
, 2012 Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation.
Abraham +52 more
core +1 more source
Journal of Biological Chemistry, 1997 The mitogen-activated protein kinase (MAPK) cascade has been intensely studied as a primary biochemical pathway through which a variety of extracellular stimuli initiate and regulate processes of cellular transformation.
J. D. English, J. Sweatt
semanticscholar +1 more source
Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106. [PDF]
, 2016 A collective body of evidence indicates that estrogen protects the heart from myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism remains incompletely understood. We have previously delineated a novel mechanism of how 17β-estradiol
Kim, Jin Kyung, Liu, Han, Luo, Tao
core +1 more source
Regulation of the G2/M Transition in Rodent Oocytes [PDF]
, 2010 Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core +2 more sources
Cinnamomum iners as Mitogen-Activated Protein Kinase Kinase (MKK1) inhibitor [PDF]
, 2009 Novel inhibitors targeting signal transductions have emerged for cancer therapies. Cinnamomum species have been reported to inhibit the proliferation of various cell lines.
How, Siew Eng +2 more
core +1 more source
European Journal of Biochemistry, 2000 Functional organization of signal transduction into protein phosphorylation cascades, such as the mitogen-activated protein kinase (MAPK) cascades, greatly enhances the sensitivity of cellular targets to external stimuli.
B. Kholodenko
semanticscholar +1 more source