Results 61 to 70 of about 673,597 (383)

A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]

arXiv, 2022
The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv  

Mitogen-activated protein kinases in apoptosis regulation [PDF]

Oncogene, 2004
Cells are continuously exposed to a variety of environmental stresses and have to decide 'to be or not to be' depending on the types and strength of stress. Among the many signaling pathways that respond to stress, mitogen-activated protein kinase (MAPK) family members are crucial for the maintenance of cells.
Josef M. Penninger, Teiji Wada
openaire   +3 more sources

Precision medicine driven by cancer systems biology [PDF]

, 2017
Molecular insights from genome and systems biology are influencing how cancer is diagnosed and treated. We critically evaluate big data challenges in precision medicine.
A Auton, A Barski, A Gros, A Hamosh, A Hauschild, A Kamburov, A Ribas, A Rotte, A Sboner, A Snyder, AD Boiko, AH Ramos, AH Shain, AK Mobley, AL Pritchard, AM Eggermont, AP Bracken, AP Feinberg, AV Danilov, B Obama, B Weide, BA Weir, BC Laurent, BM Carreno, BM Knoppers, C Krepler, C Praetorius, C Robert, C Robert, C Robert, C Robert, C Tokheim, C Zhang, CA Maher, CD Van Raamsdonk, CD Van Raamsdonk, CL Peterson, D Peng, DA Gutman, DA Scott, DG Wang, E Cerami, E Hodis, E Juengst, E Porta-Pardo, E Stronen, E Vire, EA Struys, ED Pleasance, EM Van Allen, EM Verdegaal, ES Lander, F Cruz 3rd, Fabian V. Filipp, FS Hodi, FV Filipp, FV Filipp, FV Filipp, FW Prior, G Bollag, G Chen, G Hatzivassiliou, G Santos, GQ Phan, GR Abecasis, GV Long, H Davies, H Ledford, HB Engin, HC Fan, I Bentwich, J Gao, J Guan, J Larkin, J Larkin, J Tiffen, J Timar, J Yuan, JA Curtin, JA Curtin, JC Tiffen, JC Tiffen, JD Wolchok, KT Flaherty, KT Flaherty, KT Flaherty, L Dang, L Zhang, M Chee, M Krauthammer, MA Postow, MF Berger, MS Lawrence, MS Lawrence, MT Landi, MT McCabe, N McGranahan, N Mitsiades, N Rooij van, N Wagle, NA Rizvi, P Mao, P Natarajan, PB Chapman, PB Hackett, PF Robbins, PM Pollock, R Arafeh, R Beroukhim, R Halaban, R Nazarian, RD Fleischmann, S Bamford, S Kelderman, S Malladi, S Premi, S Reardon, S Turcan, SA Forbes, SB Ng, SI Nikolaev, SJ Aronson, SK Gupta, SQ Wong, T Sjoblom, TA Knijnenburg, TJ Ley, TN Schumacher, W Hugo, W Hugo, WW Overwijk, Y Cheng, Y Khagi, Y Yang, ZA Abdel-Malek   +134 more
core   +1 more source

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Background The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk.
M. Seldin, Yonghong Meng, Hongxiu Qi, Weifei Zhu, Zeneng Wang, S. Hazen, A. Lusis, D. Shih   +7 more
semanticscholar   +1 more source

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Journal of Biomedical Science, 2017
Background MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development.
Che-Chung Yeh, Yanying Fan, Yi-Lin Yang, Michael J. Mann   +3 more
doaj   +1 more source

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. [PDF]

PLoS ONE, 2014
Prostate cancer (PCa) is the second leading cause of cancer death in the US. Death from PCa primarily results from metastasis. Mitogen-activated protein kinase kinase 4 (MAP2K4) is overexpressed in invasive PCa lesions in humans, and can be inhibited by ...
Janet M Pavese, Irene M Ogden, Eric A Voll, Xiaoke Huang, Li Xu, Borko Jovanovic, Raymond C Bergan   +6 more
doaj   +1 more source

Billion-years old proteins show the importance of N-lobe orientation in Imatinib-kinase selectivity [PDF]

arXiv, 2023
The molecular origins of proteins' functions are a combinatorial search problem in the proteins' sequence space, which requires enormous resources to solve. However, evolution has already solved this optimization problem for us, leaving behind suboptimal solutions along the way. Comparing suboptimal proteins along the evolutionary pathway, or ancestors,
arxiv  

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. [PDF]

, 2015
Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling.
Aguilar, Berenice, Grimsey, Neil J, Le, Phillip, Nizet, Victor, Puthenveedu, Manojkumar A, Smith, Thomas H, Soohoo, Amanda L, Trejo, JoAnn   +7 more
core   +2 more sources

A three-state kinetic mechanism for scaffold mediated signal transduction [PDF]

, 2008
Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert numerous physical effects on signaling pathways. To study these effects, we consider a minimal, three-state kinetic model of scaffold mediated kinase activation.
arxiv   +1 more source