Results 21 to 30 of about 229,005 (218)

Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]

F1000Research, 2022
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy, Shahab Uddin, Abdullah Azmi, Ajaz Bhat, Lubna Therachiyil, Anjana Anand   +5 more
doaj   +1 more source

Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14 [PDF]

Animal Bioscience, 2023
Objective This study aims to evaluate the target genes of gga-miR-20a-5p and the regulated immune responses in the chicken macrophage cell line, HD11, by the exosome-mediated delivery of miR-20a-5p.
Yeojin Hong, Jubi Heo, Suyeon Kang, Thi Hao Vu, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj   +1 more source

First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion

IJU Case Reports, 2021
Introduction Ductal adenocarcinoma of the prostate is a rare prostate cancer variant and associated with higher stage and greater risk of mortality. Optimal systemic therapy for metastatic ductal adenocarcinoma is not known.
Kazunori Shojo, Takeo Kosaka, Kohei Nakamura, Hiroshi Hongo, Hiroaki Kobayashi, Shuji Mikami, Hiroshi Nishihara, Mototsugu Oya   +7 more
doaj   +1 more source

Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine Threonine Kinase 3/Mixed Lineage Kinase Domain-Like and Mitogen-Activated Protein Kinase Signaling

Frontiers in Physiology, 2021
Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li, Jing Zhang, Jing Zhang, Peng-Jie Wang, Peng-Jie Wang, Zi-Wei Zhang, Zi-Wei Zhang, Jia-Qiang Huang, Jia-Qiang Huang   +8 more
doaj   +1 more source

A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia

Autophagy Reports, 2023
BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He, Jian Li, Yan Cao, Hai-Tao Wu, Li-Ying Wu   +4 more
doaj   +1 more source

Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells

Journal of Pharmacological Sciences, 2009
.: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations ...
Sung Lyea Park, You-Mie Kim, Jin-Hee Ahn, Soo Hwan Lee, Eun Joo Baik, Chang-Hyun Moon, Yi-Sook Jung   +6 more
doaj   +1 more source

Mitogen-activated Protein Kinase Kinase Kinase 1 Protects against Nickel-induced Acute Lung Injury [PDF]

Toxicological Sciences, 2008
Nickel compounds are environmental and occupational hazards that pose serious health problems and are causative factors of acute lung injury. The c-jun N-terminal kinases (JNKs) are regulated through a mitogen-activated protein (MAP) 3 kinase-MAP2 kinase cascade and have been implicated in nickel toxicity.
Maureen, Mongan, Zongqing, Tan, Liang, Chen, Zhimin, Peng, Maggie, Dietsch, Bing, Su, George, Leikauf, Ying, Xia   +7 more
openaire   +2 more sources

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure [PDF]

Proceedings of the National Academy of Sciences, 2011
Developmental eyelid closure is an evolutionarily conserved morphogenetic event requiring proliferation, differentiation, cytoskeleton reorganization, and migration of epithelial cells at the tip of the developing eyelid. Many signaling events take place during eyelid closure, but how the signals converge to regulate the ...
Esmond, Geh, Qinghang, Meng, Maureen, Mongan, Jingcai, Wang, Atsushi, Takatori, Yi, Zheng, Alvaro, Puga, Richard A, Lang, Ying, Xia   +8 more
openaire   +2 more sources

Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning [PDF]

Experimental Eye Research, 2011
We previously described the phenomenon of retinal ischemic pre-conditioning (IPC) and we have shown the role of various signaling proteins in the protective pathways, including the mitogen-activated protein kinase p38. In this study we examined the role in IPC of mitogen-activated protein kinase phosphatase-1 (MKP-1), which inactivates p38.
Roth, S, Bratton, A, Alexander, M, Savoie, B, Dreixler, JC, Shaikh, AR, Du, E, Marcet, MM   +7 more
openaire   +4 more sources

A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1

BMC Immunology, 2009
Background Mycobacterium tuberculosis (MTB) is a major cause of morbidity and mortality in the world. To combat against this pathogen, immune cells release cytokines including tumor necrosis factor-α (TNF-α), which is pivotal in the development of ...
Lau Allan SY, Lee Norris CM, Yim Howard CH, Cheung Benny KW   +3 more
doaj   +1 more source