Results 51 to 60 of about 229,005 (218)

Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line

Poultry Science, 2020
Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj   +1 more source

p38δ controls Mitogen- and Stress-activated Kinase-1 (MSK1) function in response to toll-like receptor activation in macrophages

Frontiers in Cell and Developmental Biology, 2023
Mitogen- and Stress-activated Kinase (MSK) 1 is a nuclear protein, activated by p38α Mitogen-Activated Kinase (MAPK) and extracellular signal-regulated kinase (ERK1/2), that modulate the production of certain cytokines in macrophages.
Ester Díaz-Mora, Diego González-Romero, Marta Meireles-da-Silva, Juan José Sanz-Ezquerro, Ana Cuenda   +4 more
doaj   +1 more source

A Role for the Mitogen-activated Protein Kinase Kinase Kinase 1 in Epithelial Wound Healing [PDF]

Molecular Biology of the Cell, 2006
The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals required for eyelid epithelium morphogenesis during mouse fetal development. The present study investigates the role of MEKK1 in epithelial wound healing, another activin-regulated biological process.
Maoxian, Deng, Wei-Li, Chen, Atsushi, Takatori, Zhimin, Peng, Lin, Zhang, Maureen, Mongan, Ranjani, Parthasarathy, Maureen, Sartor, Marian, Miller, Jianhua, Yang, Bing, Su, Winston W-Y, Kao, Ying, Xia   +12 more
openaire   +2 more sources

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

Cell Death and Disease, 2022
Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu   +10 more
doaj   +1 more source

Somatostatin Activation of Mitogen-Activated Protein Kinase via Somatostatin Receptor 1 (SSTR1) [PDF]

Molecular Endocrinology, 1999
AbstractHormones and growth factors regulate cell growth via the mitogen-activated protein (MAP) kinase cascade. Here we examine the actions of the hormone somatostatin on the MAP kinase cascade through one of its two major receptor subtypes, the somatostatin receptor 1 (SSTR1) stably expressed in CHO-K1 cells.
FLORIO, TULLIO, YAO H., CAREY K. D., DILLON T., STORK P. J. S.   +4 more
openaire   +3 more sources

c-Jun N-terminal Kinase Contributes to Norepinephrine-Induced Contraction Through Phosphorylation of Caldesmon in Rat Aortic Smooth Muscle

Journal of Pharmacological Sciences, 2006
.: Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK).
Youn Ri Lee, Chang-Kwon Lee, Hyo-Jun Park, Hyojin Kim, Junghwan Kim, Jaeheung Kim, Keun Sang Lee, Yun Lyul Lee, Kyung Ok Min, Bokyung Kim   +9 more
doaj   +1 more source

Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 [PDF]

Molecular and Cellular Biology, 2001
Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 ...
U, Knauf, C, Tschopp, H, Gram
openaire   +2 more sources

Distinct Genetic Alterations in the Mitogen-Activated Protein Kinase Pathway Dictate Sensitivity of Thyroid Cancer Cells to Mitogen-Activated Protein Kinase Kinase 1/2 Inhibition [PDF]

Thyroid, 2009
The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway plays an important role in papillary and anaplastic thyroid cancer (PTC and ATC) due to activating mutations in BRAF, RAS, or rearrangements in RET/PTC1. The objective of this study was to thoroughly test whether the BRAF V600E mutation predicts response to ...
Rebecca E, Schweppe, Anna A, Kerege, Vibha, Sharma, Joanna M, Poczobutt, Arthur, Gutierrez-Hartmann, Rachel L, Grzywa, Bryan R, Haugen   +6 more
openaire   +2 more sources

PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression

Molecular & Cellular Oncology, 2017
Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-
Leslie Ann Caromile, Linda H. Shapiro
doaj   +1 more source

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source