Results 301 to 310 of about 369,896 (355)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

A different MAPK, ERK5 plays a critical role in cell specification and differentiation. [PDF]

Biochem Biophys Rep
Li J, Hou X, Li X, Ji S.
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Amphiregulin attenuates sepsis-induced myocardial dysfunction by maintaining the localization of connexin43. [PDF]

Inflamm Regen
Chen M, Takamori S, Isayama K, Wang Y, Matsunaga S, Narahara S, Honsho M, Murata M, Kinugawa S, Abe K, Akahoshi T.   +10 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Correction: Biswas et al. Extracellular Vesicles in Osteogenesis: A Comprehensive Review of Mechanisms and Therapeutic Potential for Bone Regeneration. <i>Curr. Issues Mol. Biol.</i> 2025, <i>47</i>, 675. [PDF]

Curr Issues Mol Biol
Biswas S, Gangadaran P, Dhara C, Ghosh S, Phadikar SD, Chakraborty A, Mahajan AA, Mondal R, Chattopadhyay D, Banerjee T, Dey A, Ghosh S, Krishnan A, Ahn BC, Rajendran RL.   +14 more
europepmc   +1 more source

In silico molecular docking and molecular dynamics simulation of Baeckea frutescens phytochemicals as mitogen-activated protein kinase 3 (MAPK3) potential inhibitors

Hoang T. T. Trang, Ngu Thi Tra Giang, Nguyen Thi Thuy Tram, Nguyen Xuan Ha, Cao Hồng Lê   +4 more
openalex   +1 more source

Effects of Gene Mutations on the Prognosis and Treatment Response of Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy: A Meta‐Analysis and Systematic Review

iRADIOLOGY, EarlyView.
This meta‐analysis explores the impact of gene mutations on clinical outcomes in locally advanced colorectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy. KRAS mutations are associated with poorer overall survival and lower treatment response, including pathologic complete response.
Jisheng Chen, Daofeng Wang, Xinlong Shi
wiley   +1 more source

Bibliometric analysis and core target identification of network pharmacology on neuroinflammation in central nervous system disorders: Trends, collaborations, and future directions. [PDF]

Neuroprotection
Zhang Y, Hou S, Li J, Wang W, Jia S, Wang X, Xia Y, Wang Y.   +7 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source