Results 281 to 290 of about 369,896 (355)

Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus

, 2017
Bárbara de Almeida Rodrigues, Gabriel Keine Kuga, Vítor Rosetto Muñoz, Rafael Calais Gaspar, Mariana Tavares, José Diego Botezelli, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, Fernando Moreira Simabuco, Eduardo R. Ropelle, José Rodrigo Pauli   +11 more
openalex   +2 more sources

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers. [PDF]

Cancer Innov
Khatun S, Sohel M, Barman Z, Salma U, Arbia L, Sarker MR, Jame JA, Dey BR, Parvin S, Shuvo MSP, Islam MS, Mannan T, Das SR, Hasan MM.   +13 more
europepmc   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, EarlyView.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

Astaxanthin provides antioxidant protection in rats with chronic nonbacterial prostatitis by regulating the MAPK signaling pathway. [PDF]

Transl Androl Urol
Jiang J, Song H, Chen J, Zeng Y, Zhu H, Ding M, Liu L.   +6 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Investigating the Roles of MAPKs as Precision Oncology Targets: A Multi-cancer Expression and Survival Study. [PDF]

Cancer Genomics Proteomics
Sulaimani MN, Singh P, Saeed MU, Zaidi S, Hussain A, Alajmi MF, Shamsi A, Dohare R, Hassan MI.   +8 more
europepmc   +1 more source

Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) displays a p-JNK-MAPK substrate preference in astrocytes in vitro

, 2014
Christian Ndong, Russell P. Landry, Madhurima Saha, E. Alfonso Romero‐Sandoval   +3 more
openalex   +2 more sources

Single‐cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection

iMeta, EarlyView.
We utilized single‐cell RNA sequencing (scRNA‐seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation.
Liang Shao, Fan Hu, Ling‐Na Zhao, Jian‐Ping Luo, Peng‐Tao Zou, Xiu Liu, Shao‐Yi Zheng, Cong Chen, Lin‐Xiong Ye, Yu‐Xuan Zhou, Jiaqi Zhang, Kaidi Jin, Ping Zhang   +12 more
wiley   +1 more source

Choline kinase α interacts with epidermal growth factor receptor to activate the mitogen-activated protein kinase pathway and contributes to glioma tumorigenesis. [PDF]

Chin Med J (Engl)
Zou Y, Wu X, Liu Y, Zhao Y, Liu H, Feng J, Gao P, Ma H.   +7 more
europepmc   +1 more source