Results 271 to 280 of about 395,145 (302)
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Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase
Science, 1998MAP kinase phosphatase–3 (MKP-3) dephosphorylates phosphotyrosine and phosphothreonine and inactivates selectively ERK family mitogen-activated protein (MAP) kinases. MKP-3 was activated by direct binding to purified ERK2. Activation was independent of protein kinase activity and required binding of ERK2 to the noncatalytic amino-terminus of MKP-3 ...
M, Camps +7 more
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Biochemical and Biophysical Research Communications, 2000
The activation of both phosphatidylinositol 3-kinase (PI3-kinase) and p38 mitogen-activated protein kinase (p38 MAPK) is required for muscle differentiation. However, it is not known whether the signals from these two kinases interact during this process. In this work, we have investigated this using H9c2 cardiac myoblasts.
Y K, Chun +10 more
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The activation of both phosphatidylinositol 3-kinase (PI3-kinase) and p38 mitogen-activated protein kinase (p38 MAPK) is required for muscle differentiation. However, it is not known whether the signals from these two kinases interact during this process. In this work, we have investigated this using H9c2 cardiac myoblasts.
Y K, Chun +10 more
openaire +2 more sources
Experimental Eye Research, 2002
The current understanding of the cellular signal transduction system is that cells initially respond to outside stimuli, such as growth factors or neurotransmitters, through ligand binding to the respective growth factor receptors or the G-protein-coupled receptors, to initiate transduction of the stimulus.
Steven D, Zatechka, Marjorie F, Lou
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The current understanding of the cellular signal transduction system is that cells initially respond to outside stimuli, such as growth factors or neurotransmitters, through ligand binding to the respective growth factor receptors or the G-protein-coupled receptors, to initiate transduction of the stimulus.
Steven D, Zatechka, Marjorie F, Lou
openaire +2 more sources
Clinical and Experimental Pharmacology and Physiology, 1999
1. Interstitial fibroblast proliferation is an elemental feature in the development of cardiac fibrosis. The effects of inhibitors of the intracellular signalling proteins, MEK, a kinase involved in the mitogen‐activated protein kinase (MAPK) pathway and phosphatidylinositol 3‐kinase (PI3‐K), were tested on growth of cultured human cardiac fibroblasts ...
S, Hafizi, A H, Chester, M H, Yacoub
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1. Interstitial fibroblast proliferation is an elemental feature in the development of cardiac fibrosis. The effects of inhibitors of the intracellular signalling proteins, MEK, a kinase involved in the mitogen‐activated protein kinase (MAPK) pathway and phosphatidylinositol 3‐kinase (PI3‐K), were tested on growth of cultured human cardiac fibroblasts ...
S, Hafizi, A H, Chester, M H, Yacoub
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The protein stannin binds 14-3-3ζ and modulates mitogen-activated protein kinase signaling
Molecular Brain Research, 2005The molecular mechanisms underlying the selective toxicity of trimethyltin (TMT) remain unclear. Stannin (Snn), a protein preferentially expressed in TMT-sensitive cells, provides a direct link to the molecular basis for TMT toxicity. Recent evidence demonstrated that Snn peptides bind and de-alkylate TMT to dimethyltin (DMT); Snn may mediate both TMT ...
Collin E, Davidson +3 more
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Journal of Molecular and Cellular Cardiology, 2002
Naomi W. Court +3 more
semanticscholar +1 more source
Naomi W. Court +3 more
semanticscholar +1 more source
Mitogen‐activated protein kinase cascades in plant signaling
Journal of Integrative Plant Biology, 2022Shuqun Zhang, Mengmeng Zhang
exaly