Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3. [PDF]
J Biol Chem, 2017 The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-
Bassi R +7 more
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Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]
PLoS ONE, 2013 Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and bioavailability. Malvidin
Eszter Bognar +7 more
doaj +10 more sources
In-silico genome wide analysis of Mitogen activated protein kinase kinase kinase gene family in C. sinensis [PDF]
PLoS ONE, 2021 Mitogen activated protein kinase kinase kinase (MAPKKK) form the upstream component of MAPK cascade. It is well characterized in several plants such as Arabidopsis and rice however the knowledge about MAPKKKs in tea plant is largely unknown.
Abhirup Paul +4 more
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Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]
PLoS ONE, 2008 Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay +9 more
doaj +7 more sources
Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways [PDF]
Journal of Ginseng Research, 2016 Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin +7 more
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Mitogen-activated protein kinase kinase 7 in inflammatory, cancer, and neurological diseases [PDF]
Frontiers in Cell and Developmental Biology, 2022 Stress-activated mitogen-activated protein kinase kinase 7 (MKK7) is a member of the dual-specificity mitogen-activated protein kinase family. In the human body, MKK7 controls essential physiological processes, including but not limited to proliferation ...
Amada D. Caliz +6 more
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Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks [PDF]
Frontiers in Plant Science, 2020 Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan +3 more
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Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis? [PDF]
Hepatology Communications, 2019 While intensive investigations on MAPK signaling pathways discovered their critical functions in the development of obesity as well as steatohepatitis, the studies have also suggested their complexity. MKP5, a negative regulator of MAPK signaling, contributes to the improvement of steatohepatitis.
Kouichi Miura, Hironori Yamamoto
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MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization. [PDF]
PLoS ONE, 2012 BACKGROUND: The response of the postnatal heart to growth and stress stimuli includes activation of a network of signal transduction cascades, including the stress activated protein kinases such as p38 mitogen-activated protein kinase (MAPK), c-Jun NH2 ...
Hamid el Azzouzi +5 more
doaj +5 more sources
RelA and mitogen-activated protein kinase kinase kinases potently enhance lentiviral vector production [PDF]
Biochemistry and Biophysics ReportsThe growing demands for gene therapy have encouraged development of safe and efficient lentiviral vector (LV) preparation. While much progress has been made in this field, it remains to be explored how to boost its production from producer cells.
Shoji Yamaoka
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