Results 151 to 160 of about 402,236 (378)

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

OsSTS, a Novel Allele of Mitogen-Activated Protein Kinase Kinase 4 (OsMKK4), Controls Grain Size and Salt Tolerance in Rice. [PDF]

Rice (N Y), 2023
Liu J, Shen L, Guo L, Zhang G, Gao Z, Zhu L, Hu J, Dong G, Ren D, Zhang Q, Li Q, Zeng D, Yan C, Qian Q.   +13 more
europepmc   +1 more source

Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS [PDF]

, 2005
In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated ...
A Calipel, A Gorden, A van Elsas, A Weber, A-M Borgstein, AS Yazdi, AW Stitt, C Cohen, C Out, CM Mooy, CM Mooy, CN Soparker, D Rimoldi, E Kilic, F Cruz III, F van Nieuwpoort, GP Luyten, H Davies, H Tsao, I de Waard-Siebinga, J Alsina, J Dong, J Graells, J Kan-Mitchell, J Reifenberger, JL Maldonado, JM Stahl, K Omholt, K Satyamoorthy, K Sisley, L Packer, M Diener-West, M J Jager, M Shinozaki, M Stark, MS Brose, N A Gruis, N K Hayward, NC Naus, P Guldberg, P Uribe, P van der Velden, PA van der Velden, PM Pollock, R Dijkman, R Kumar, R Kumar, RJ Scott, S Pavey, SA Miller, SC Edmunds, TG Sheidow, W Zuidervaart, Y Cohen, Y Cohen   +54 more
core   +2 more sources

Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen. [PDF]

, 1988
Arthur R. Buckley, Paul D. Crowe, Diane H. Russell   +2 more
openalex   +1 more source

Editorial: Mitogen Activated Protein Kinases [PDF]

Frontiers in Cell and Developmental Biology, 2017
José Manuel Lozano, Jose M. Lizcano, Ana Cuenda   +2 more
openaire   +4 more sources

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 5001-5012, December 2022., 2022
Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). To elucidate circulating stimulators for nerve invasion, the authors evaluated the stimulant activity and the inhibitory effects of IL‐6/gp130 axis. Biological activity of IL‐6/gp130 axis promoted nerve invasion in murine model and was upregulated in ...
Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Masayuki Yamaguchi, Masami Suzuki, Minoru Narita, Toshikatsu Kawasaki, Atsushi Ochiai   +9 more
wiley   +1 more source

Calcineurin Contributes to the Enhancing Effect of Adenosine on Nerve Growth Factor-Induced Neurite Outgrowth via the Decreased Duration of p38 Mitogen-Activated Protein Kinase Phosphorylation

Journal of Pharmacological Sciences, 2004
Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 ...
Yoshikage Muroi, Toshiaki Ishii, Kentarou Teramoto, Masatoshi Hori, Masakazu Nishimura   +4 more
doaj  

Cardiac imaging in RASopathies/mitogen activated protein kinase syndromes

Cardiogenetics, 2014
RASopathies include a spectrum of disorders due to dysregulation of RAS/mitogen activated protein kinase pathway that plays an essential role in the control of the cell cycle and differentiation.
Rita Gravino, Giuseppe Pacileo
doaj   +1 more source