[Retracted] MicroRNA‑136 inhibits prostate cancer cell proliferation and invasion by directly targeting mitogen‑activated protein kinase kinase 4. [PDF]
Mol Med Rep, 2023 Zhu Y, Shao S, Pan H, Cheng Z, Rui X.
europepmc +1 more source
Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]
, 2007 c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L +3 more
core +2 more sources
Advanced Science, EarlyView.The salivary sheath protein myosin from SBPH is critical for the formation of the salivary sheath and feeding. However, myosin functions as a HAMP and triggered plant BAK1‐mediated PTI responses, which include the activation of calcium signaling pathways, MAPK phosphorylation, ROS bursts, and cell death, thereby triggering JA pathway.
Liangxuan Qi +12 more
wiley +1 more source
Latent periodicity of serine-threonine and tyrosine protein kinases and another protein families [PDF]
Molekularnuya Biologiya (Russian), vol.39, N3, 2005, 2004 We identified latent periodicity in catalytic domains of approximately 85% of serine/threonine and tyrosine protein kinases. Similar results were obtained for other 22 protein domains. We also designed the method of noise decomposition, which is aimed to distinguish between different periodicity types of the same period length. The method is to be used
arxiv
Phosphoproteome Reveals Extracellular Regulated Protein Kinase Phosphorylation Mediated by Mitogen-Activated Protein Kinase Kinase-Regulating Granulosa Cell Apoptosis in Broody Geese. [PDF]
Int J Mol Sci, 2023 Zhao S +8 more
europepmc +1 more source
MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity. [PDF]
, 1994 Anne M. Gardner +3 more
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COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma
Advanced Science, EarlyView.COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo +15 more
wiley +1 more source
Putative mechanism of a multivitamin treatment against insulin resistance
AdipocyteInsulin resistance is caused by the abnormal secretion of proinflammatory cytokines in adipose tissue, which is induced by an increase in lipid accumulation in adipocytes, hepatocytes, and myocytes. The inflammatory pathway involves multiple targets such
José Antonio Palma-Jacinto +4 more
doaj +1 more source
A Monte Carlo study of ligand-dependent integrin signal initiation [PDF]
arXiv, 2010 Integrins are allosteric cell adhesion receptors that control many important processes, including cell migration, proliferation, and apoptosis. Ligand binding activates integrins by stabilizing an integrin conformation with separated cytoplasmic tails, thus enabling the binding of proteins that mediate cytoplasmic signaling.
arxiv
Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma. [PDF]
Neurooncol Adv, 2023 Khan S +9 more
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