Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases in Regenerative Myogenesis and Muscular Dystrophy [PDF]
, 2012 The mitogen-activated protein kinase (MAPK) signal transduction pathway is required to promote skeletal myogenesis and maintain skeletal muscle function. Although it has been long appreciated that the MAPK pathway plays a critical role in skeletal myogenesis it is still unclear as to whether the MAPKs are involved in the development of skeletal muscle ...
Anton M. Bennett, Hao Shi
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Advanced Science, EarlyView.Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu +21 more
wiley +1 more source
Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells. [PDF]
J Vet Med Sci, 2023 Yamamoto M, Fujiwara N.
europepmc +1 more source
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor [PDF]
, 1992 Sarah Traverse +4 more
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Advanced Science, EarlyView.By employing a combination of single cell and spatial transcriptomic sequencing, this study presents a stereoscopic response of rice leaf to Magnaporthe oryzae infection. The vascular tissues mount defenses by producing phytoalexins. The immune strength is stronger toward the rice leaf tip than that of the leaf base.
Wei Wang +15 more
wiley +1 more source
IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59 [PDF]
, 1994 Julian D. Watts +4 more
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Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
Advanced Science, EarlyView.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation. [PDF]
Acta Crystallogr F Struct Biol Commun, 2021 Nakae S +6 more
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Advanced Science, EarlyView.The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang +13 more
wiley +1 more source