Results 171 to 180 of about 408,194 (307)

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

Arthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Mitogen-activated protein kinase kinase 4 (MKK4) as a promising therapeutic target in liver diseases: a review. [PDF]

J Enzyme Inhib Med Chem
Liu P, Liu Y, Cheng L, Bao T, Li J, Wu J, Han J, Li T, Zhang D.   +8 more
europepmc   +1 more source

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 [PDF]

, 2020
openaire   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Overcoming reduced glucocorticoid sensitivity in airway disease:molecular mechanisms and therapeutic approaches [PDF]

, 2010
Abraham, Adcock, Ali, Allfrey, Auphan, Barnes, Barnes, Barnes, Barnes, Bartholome, Bartling, Bartling, Bateman, Beesley, Bergeron, Bhavsar, Bhavsar, Bourbeau, Cai, Calverley, Carmichael, Carrabino, Charmandari, Chen, Cho, Chung, Chung, Chung, Ciencewicki, Condliffe, Cosio, Cosio, Culpitt, Culpitt, Denslow, Duma, Evans, Ferreira, Fitzpatrick, Freedman, Gagliardo, Galasinski, Galliher-Beckley, Galliher-Beckley, Goleva, Gross, Gross, Hakonarson, Haller, Hew, Hogg, Hwang, Ian M. Adcock, Irusen, Ito, Ito, Ito, Ito, Ito, Ito, Jatakanon, John, John A. Marwick, Karp, Keatings, Kian Fan Chung, King, Kino, Kitagawa, Kleiman, Knoepfler, Konstan, Korn, Kovacs, Krstic, Kumar, Kumar, Kurashima, Laffargue, Langhoff, Lee, Lee, Lewis-Tuffin, Li, Li, Liu, Lu, Macedo, Mak, Mannino, Marone, Marwick, Marwick, Marwick, Marwick, Marwick, Matysiak, Meagher, Medicherla, Meja, Miller, Molnarfi, Moore, Murphy, Muselet-Charlier, Onda, Osoata, OʼSullivan, Pace, Patel, Pratt, Pujols, Pujols, Rahman, Rahman, Raia, Reichardt, Renda, Rennard, Rhen, Rogatsky, Rommel, Rottner, Rumora, Saccani, Sadhu, Sasaki, Schacke, Scheinman, Schermer, Sethi, Silverstein, Smith, Smolonska, Stav, Strickland, Suissa, Szatmuíry, Thomson, Tomlinson, Tuckermann, Tudhope, Ukena, Usmani, van Rensen, Verhaeghe, Ward, Ward, Wood, Wright, Young   +150 more
core   +1 more source

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3. [PDF]

Mol Biomed
Chang SY, Gu B, Xiong Y, Zhao MS, Li L, Liu Y, Wang BQ, Li GQ, Du RL, Zhang XD.   +9 more
europepmc   +1 more source

Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2-5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly. [PDF]

Aging Cell, 2022
Zhou XY, Ying CJ, Hu B, Zhang YS, Gan T, Zhu YD, Wang N, Li AA, Song YJ.   +8 more
europepmc   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

The prognostic value of mitogen-activated protein kinase kinase in liver hepatocellular carcinoma by bioinformatics. [PDF]

Medicine (Baltimore)
Dong S, Jing S, Qinshun J, Huaning W, Rong Z.   +4 more
europepmc   +1 more source