Rice mitogen activated protein kinase kinase and mitogen activated protein kinase interaction network revealed by in-silico docking and yeast two-hybrid approaches. [PDF]
PLoS ONE, 2013 Protein-protein interaction is one of the crucial ways to decipher the functions of proteins and to understand their role in complex pathways at cellular level.
Dhammaprakash Pandhari Wankhede +3 more
doaj +1 more source
Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
Effect of MST1 on Invasion and Migration of Colon Cancer through Mitogen-Activated Protein Kinase/Extracellular SignalRegulated Kinase Signal Pathway [PDF]
, 2021 To explore the effect of mammalian STE20 like protein kinase 1 on colon cancer invasion and metastasis through mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.
Divya, G.Ratnakumari, V.Raju
core +2 more sources
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. [PDF]
PLoS ONE, 2017 The ovary is the main regulator of female fertility. Granulosa cell dysfunction may be involved in various reproductive endocrine disorders. Here we investigated the effect of insulin resistance on the metabolism and function of ovarian granulosa cells ...
Linghui Kong +8 more
doaj +1 more source
Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood
Acta Dermato-Venereologica, 2022 Pyogenic granuloma is one of the most common vascular tumours. The cause of pyogenic granuloma was previously thought to be an inflammatory reaction with consecutive stimulation of endothelial cell proliferation.
Katharina Strobel +6 more
doaj +1 more source
Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8. [PDF]
PLoS ONE, 2009 Kinases are pivotal regulators of cellular physiology. The human genome contains more than 500 putative kinases, which exert their action via the phosphorylation of specific substrates.
Kaushal Parikh +8 more
doaj +1 more source
Kinase Activity Profiling of Gram-Negative Pneumonia [PDF]
, 2011 Pneumonia is a severe disease with high morbidity and mortality. A major causative pathogen is the Gram-negative bacterium Klebsiella (K.) pneumoniae. Kinases play an integral role in the transduction of intracellular signaling cascades and regulate a ...
Diks, Sander H. +4 more
core +5 more sources
Fucoidan Inhibits Smooth Muscle Cell Proliferation and Reduces Mitogen-activated Protein Kinase Activity [PDF]
, 2000 Objectives and design: fucoidan has previously been shown to inhibit the proliferation of arterial smooth muscle cells both in animal models and in vitro.
Gaciong, Z +5 more
core +1 more source
Frontiers in Plant Science, 2015 The tripartite mitogen-activated protein kinase (MAPK) signaling cascades have been implicated in plant growth, development, and environment adaptation, but a comprehensive understanding of MAPK signaling at genome-wide level is limited in Capsicum ...
Shuilin eHe +26 more
doaj +1 more source