Results 11 to 20 of about 408,194 (307)

Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks

Frontiers in Plant Science, 2020
Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan, Lixia Pan, Ive De Smet, Ive De Smet   +3 more
doaj   +1 more source

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase [PDF]

, 2011
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity.
Abraham, Alizadeh, Angus, Asaduzzaman, Bellahcene, Benjamini, Bernard, Boucek, Branger, Chang, Checchia, Chen, Chen, Cheryl A. Hemingway, Chopra, Crackower, Cuenda, Cvijanovich, David A. Relman, Dhingra, Dong, Fourrier, Gentleman, Haralambous, Hariklia Eleftherohorinou, Hilger, Hotchkiss, Hubble, Jayne L. Dennis, Joanne L. Franklin, Kaminska, Kanehisa, Kishimoto, Kumar, Leblais, Levin, Liu, Liu, Ma, Martin, Mi, Michael Griffiths, Michael Levin, Mockridge, Narazaki, Nazima Pathan, Opal, Osuchowski, Padkin, Parasrampuria, Pathan, Pathan, Popper, Riedemann, Schumann, Shanley, Sian E. Harding, Simon J. Waddell, Smyth, Song, Su, Talmor, Victoria J. Wright, Waage, Wang, Watson, Yang, Yu, Zarubin   +68 more
core   +1 more source

PREDICTION OF 3D STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 USING ALPHAFOLD 2 AND SIMULATION OF ITS INTERACTION WITH MITOGEN-ACTIVATED PROTEIN KINASE 6 IN ARABIDOPSIS THALIANA [PDF]

Journal of Plant Development
Arabidopsis thaliana mitogen-activated protein kinase (MPK or MAPK) signaling network plays significant roles in various cellular processes. The three-dimensional structure of mitogen-activated protein kinase kinase 2 (MKK2), an upstream kinase in the ...
Sameer KHAN, Tim XING
doaj   +1 more source

Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8. [PDF]

PLoS ONE, 2009
Kinases are pivotal regulators of cellular physiology. The human genome contains more than 500 putative kinases, which exert their action via the phosphorylation of specific substrates.
Kaushal Parikh, Sander H Diks, Jurriaan H B Tuynman, Auke Verhaar, Mark Löwenberg, Daan W Hommes, Jos Joore, Akhilesh Pandey, Maikel P Peppelenbosch   +8 more
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Genome-wide identification and transcriptional expression analysis of mitogen-activated protein kinase and mitogen-activated protein kinase kinase genes in Capsicum annuum

Frontiers in Plant Science, 2015
The tripartite mitogen-activated protein kinase (MAPK) signaling cascades have been implicated in plant growth, development, and environment adaptation, but a comprehensive understanding of MAPK signaling at genome-wide level is limited in Capsicum ...
Shuilin eHe, zhiqin eliu, zhiqin eliu, lanping eshi, lanping eshi, yanyan eliu, yanyan eliu, lei eshen, lei eshen, sheng eyang, sheng eyang, jinsen ecai, qian etang, qian etang, huanxin eyu, huanxin eyu, rongzhang ewang, rongzhang ewang, jiayu ewen, jiayu ewen, youquan elin, youquan elin, jiong ehu, jiong ehu, cailing eliu, cailing eliu, shaoliang emou   +26 more
doaj   +1 more source

The many-faced KSR1: a tumor suppressor in breast cancer [PDF]

, 2015
Emerging evidence supports the dual function of kinase suppressor of Ras 1 (KSR1) as an active kinase and a scaffold, although it has been extensively referred as a pseudokinase, due to the absence of key residues in its catalytic domain [1, 2].
Giamas, Georgios, Stebbing, Justin, Zhang, Hua   +2 more
core   +2 more sources

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways

Journal of Ginseng Research, 2016
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin, Wei Yang, Dongxu Feng, Xinwen Wang, Muyao Qi, Tianxin Du, Hongzhi Sun, Shufang Wu   +7 more
doaj   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C., Bibby, Bo Martin, Funding, Anne, Iversen, Lars, Johansen, Claus, Kragballe, Knud, Lilleholt, Louise Langer   +6 more
core   +3 more sources