Results 221 to 230 of about 402,236 (378)

Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes [PDF]

, 1994
M K Liu, Roger W. Brownsey, Neil E. Reiner   +2 more
openalex   +1 more source

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

Arthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Pyrus ussuriensis Maxim 70% ethanol eluted fraction ameliorates inflammation and oxidative stress in LPS‐induced inflammation in vitro and in vivo

Food Science &Nutrition, Volume 11, Issue 1, Page 458-469, January 2023., 2023
In this work, we demonstrated that PUM70 specifically suppressed LPS‐mediated inflammatory responses. Notably, PUM70 treatment inhibited LPS‐induced lung damage, pro‐inflammatory cytokine production, and reduced macrophage infiltration in the lungs. Mechanistically, PUM70 suppressed LPS‐induced inflammation and oxidative stress via the Nrf2/HO‐1 and ...
Fei Peng, Xin Ren, Bin Du, Yuedong Yang
wiley   +1 more source

Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2-5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly. [PDF]

Aging Cell, 2022
Zhou XY, Ying CJ, Hu B, Zhang YS, Gan T, Zhu YD, Wang N, Li AA, Song YJ.   +8 more
europepmc   +1 more source

Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen‐activated protein kinase

, 1994
Stephen W. Young, Martin Dickens, Jeremy M. Tavaré   +2 more
openalex   +1 more source

Alcohol extracts of Chinese bayberry branch induce S‐phase arrest and apoptosis in HepG2 cells

Food Science &Nutrition, Volume 11, Issue 1, Page 493-503, January 2023., 2023
The alcohol extracts of Chinese bayberry Myrica rubra branches (MRBE) effectively inhibited the proliferation of HepG2 cells by inducing cell cycle arrest in S phase and promoting apoptosis, with this arrest potentially mediated by the activation of p21–Cyclin–CDK (cyclin‐dependent kinase) complex signaling pathways.
Yuanyuan Zheng, Zheping Yu, Yougui Li, Shi Zhong, Yuqing Sun, Li Sun, Xiliang Zheng, Xingjiang Qi, Shuwen Zhang   +8 more
wiley   +1 more source

Activation of the mitogen-activated protein kinase pathway in Triton X-100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells. [PDF]

, 1993
Paul Dent, Jianguo Wu, Guillermo Romero, L A Vincent, David Castle, Thomas W. Sturgill   +5 more
openalex   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

, 1993
Takahito Itoh, Kozo Kaibuchi, Tomomi Masuda, Tadashi Yamamoto, Yoshiharu Matsuura, A. Maeda, Kazuo Shimizu, Yoshimi Takai   +7 more
openalex   +1 more source

Molecular cloning and sequencing of a carp cDNA encoding mitogen-activated protein kinase kinase [PDF]

, 1994
Chang-Jen Huang, Ming‐Shyue Lee, Geen‐Dong Chang, Fore‐Lien Huang, Tung‐Bin Lo   +4 more
openalex   +1 more source