Results 241 to 250 of about 402,236 (378)

Identification of sinensetin as a selective inhibitor for mitogen-activated protein kinase kinase 6 and an anticancer agent for non-small cell lung cancer. [PDF]

Am J Cancer Res
Xie X, Shin YR, Kim TS, Seong YS, Yi YW, Kim DJ.   +5 more
europepmc   +1 more source

Combination therapies with mitogen-activated protein kinase kinase inhibitors and immune checkpoint inhibitors in non-small cell lung cancer. [PDF]

Chin Med J (Engl), 2020
Xu JL, Wang XZ, Jiang HN, Chen Y, Wang R, Shu YQ.   +5 more
europepmc   +1 more source

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

, 1994
Diane Milne, David G. Campbell, F. Barry Caudwell, David W. Meek   +3 more
openalex   +1 more source

Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site [PDF]

, 1997
Maria Adams, Mauricio J. Reginato, Dalei Shao, Mitchell A. Lazar, Krishna Chatterjee   +4 more
openalex   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Mitogen-activated protein kinase kinase kinase 1 facilitates the temozolomide resistance and migration of GBM via the MEK/ERK signalling. [PDF]

J Cell Mol Med
Wu S, Xue S, Tang Y, Zhao W, Zheng M, Cheng Z, Hu X, Sun J, Ren J.   +8 more
europepmc   +1 more source

Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer.

Am J Physiol Gastrointest Liver Physiol, 2021
Shneider BL, Cortes-Santiago N, Schady DA, Krishnamoorthy S, Thevananther S, Rajapakshe K, Perera D, Huang S, Coarfa C.   +8 more
europepmc   +1 more source

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

, 1993
Ilja Vietor, Paul Schwenger, W Li, Joseph Schlessinger, J Vilček   +4 more
openalex   +1 more source

The Mitogen-activated Protein (MAP) Kinase p38 and Its Upstream Activator MAP Kinase Kinase 6 Are Involved in the Activation of Signal Transducer and Activator of Transcription by Hyperosmolarity [PDF]

, 1999
Johannes G. Bode, Petros Gatsios, Stephan Ludwig, Ulf R. Rapp, Dieter Häussinger, Peter C. Heinrich, Lutz Graeve   +6 more
openalex   +1 more source

Germline selection of PTPN11 (HGNC:9644) variants make a major contribution to both Noonan syndrome's high birth rate and the transmission of sporadic cancer variants resulting in fetal abnormality

Human Mutation, Volume 43, Issue 12, Page 2205-2221, December 2022., 2022
Mutation frequency heat map of spontaneous PTPN11 variants show spatial clustering in the testis due to germline selection explaining the high birth incidence of Noonan syndrome. Some somatic PTPN11 cancer mutations are similarly clustered in testis. Abstract Some spontaneous germline gain‐of‐function mutations promote spermatogonial stem cell clonal ...
Jordan Eboreime, Soo‐Kyung Choi, Song‐Ro Yoon, Anastasiia Sadybekov, Vsevolod Katritch, Peter Calabrese, Norman Arnheim   +6 more
wiley   +1 more source