Results 241 to 250 of about 408,194 (307)

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Med Research, EarlyView.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao, Min Ding, Zhixue Min, Yihan Dong, Xuanye Cao, Qiang Lu, Cong Chen, Yahui Wu, Xin Guo, Zhen Wu, Jing Xie, Dan Xu, Haizhen Chen, Rongli Xie, Jian Fei   +14 more
wiley   +1 more source

Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo

Nano Select, EarlyView.
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng, Yi Yu, Mingyi Chen, Weibin Wu, Chunyan Zhu, Caisheng Wu, Weihua Li, Zehua Liu, Qiang Xie   +8 more
wiley   +1 more source

Calcium signaling in plant defense

New Plant Protection, EarlyView.
Calcium signaling acts as a central hub in plant immunity, translating pathogen perception into defense responses. This review highlights the channels, sensors, and signaling networks involved, and discusses how pathogens subvert calcium dynamics, as well as how this knowledge may inspire innovative strategies for engineering durable crop resistance ...
Lifan Sun, Yu Wang, Jie Zhang
wiley   +1 more source

Strategic risk assessment in oncology: Utilizing single-agent activity to boost combination therapy approvals. [PDF]

Contemp Clin Trials Commun
Kasim A, Anastasiou M, Loizou E, Dimakakos A, Georganaki M, Mourelatos I, Karelis P, Esposito M, Zhou H, Chen TT, Skaltsas D, Stockman P.   +11 more
europepmc   +1 more source

Plasmodesmata‐located proteins: The molecular hubs in noncell‐autonomous immunity

New Plant Protection, EarlyView.
Plasmodesmata serve as critical battlefields for plant immunity, regulated by diverse proteins. This article provides a comprehensive review of the regulatory mechanisms, challenges, and future directions concerning proteins located within plasmodesmata and their roles in plant defense responses.
Zheng Wu, Xiaoyi Shan
wiley   +1 more source

ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
Forsthoefel, D, Hartman, M, Hofmeister, J K, Hume, D A, Ostrowski, M C, Schaffner, A E, Smith, J L, Wei, G   +7 more
core  

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5. [PDF]

Front Immunol
Yang B, Fang G, Marx I, Liu G, Skouras S, Sharma K, Walther DM, Bollinger Martinez S, Hubeau C, Shi Y, De Savi C, Huang X, Huhn A, Sawant R, Proctor WR, Dixit VS, Dong H, Weiss MM, Mainolfi N, Slavin A, Long AJ, Williams JA, Byrne FR.   +22 more
europepmc   +1 more source

Retraction: Berberine Chloride Mediates Its Anti-Leishmanial Activity via Differential Regulation of the Mitogen Activated Protein Kinase Pathway in Macrophages. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source