Results 21 to 30 of about 402,236 (378)

Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. [PDF]

PLoS ONE, 2014
Prostate cancer (PCa) is the second leading cause of cancer death in the US. Death from PCa primarily results from metastasis. Mitogen-activated protein kinase kinase 4 (MAP2K4) is overexpressed in invasive PCa lesions in humans, and can be inhibited by ...
Janet M Pavese, Irene M Ogden, Eric A Voll, Xiaoke Huang, Li Xu, Borko Jovanovic, Raymond C Bergan   +6 more
doaj   +1 more source

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]

, 2017
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie, Fujimori-Tonou, Noriko, Hirayama, Jun, Iwatsuki, Mamiko, Kaneko, Asahito, Kawasaki, Hiroshi, Marth, Jamey D, Matsuoka, Masato, Miyamura, Norio, Nishina, Hiroshi, Okamoto-Uchida, Yoshimi, Penninger, Josef M, Shibata, Shigenobu, Yamanaka, Koji, Yamanashi, Yuji, Yamasaki, Tokiwa   +15 more
core   +2 more sources

Activation of Mitogen-activated Protein Kinase (Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase) Cascade by Aldosterone [PDF]

Molecular Biology of the Cell, 2002
Aldosterone in some tissues increases expression of the mRNA encoding the small monomeric G protein Ki-RasA. Renal A6 epithelial cells were used to determine whether induction of Ki-ras leads to concomitant increases in the total as well as active levels of Ki-RasA and whether this then leads to subsequent activation of its effector mitogen-activated ...
Eunan Hendron, James D. Stockand
openaire   +3 more sources

ARABIDOPSIS ATMKK1 KNOCKOUT MUTANT FLOWERS UNDER SHORT DAY CONDITIONS [PDF]

Journal of Plant Development
There are a variety of conditions that regulate flowering time in Arabidopsis, but there are no reported instances mitogen-activated protein kinase pathways playing a decisive role in flowering time.
Chad CONROY, Khadijah M. NIZAM, Tim XING
doaj   +1 more source

Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]

PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv   +1 more source

β-Adrenergic Receptor Activation Inhibits Keratinocyte Migration via a Cyclic Adenosine Monophosphate-independent Mechanism [PDF]

, 2002
There is increasing evidence that G-protein-coupled receptors cross-talk with growth factor receptor-mediated signal transduction in a variety of cell types.
Chen, Jin, Hoffman, Brian B., Rivkah Isseroff, R.   +2 more
core   +1 more source

Multiple roles of the mitogen‐activated protein kinase kinase/mitogen‐activated protein kinase cascade in Xenopus laevis [PDF]

Development, Growth & Differentiation, 1996
Mitogen‐activated protein kinase (MAPK) was originally identified as a serine/threonine protein kinase that is rapidly activated in response to various growth factors and tumor promoters in mammalian cultured cells. The kinase cascade including MAPK and its direct activator, MAPK kinase (MAPKK), is now believed to transmit various extracellular signals
Hidetaka Kosako, Yukiko Gotoh, Eisuke Nishida   +2 more
openaire   +3 more sources

Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase [PDF]

, 2011
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity.
Abraham, Alizadeh, Angus, Asaduzzaman, Bellahcene, Benjamini, Bernard, Boucek, Branger, Chang, Checchia, Chen, Chen, Cheryl A. Hemingway, Chopra, Crackower, Cuenda, Cvijanovich, David A. Relman, Dhingra, Dong, Fourrier, Gentleman, Haralambous, Hariklia Eleftherohorinou, Hilger, Hotchkiss, Hubble, Jayne L. Dennis, Joanne L. Franklin, Kaminska, Kanehisa, Kishimoto, Kumar, Leblais, Levin, Liu, Liu, Ma, Martin, Mi, Michael Griffiths, Michael Levin, Mockridge, Narazaki, Nazima Pathan, Opal, Osuchowski, Padkin, Parasrampuria, Pathan, Pathan, Popper, Riedemann, Schumann, Shanley, Sian E. Harding, Simon J. Waddell, Smyth, Song, Su, Talmor, Victoria J. Wright, Waage, Wang, Watson, Yang, Yu, Zarubin   +68 more
core   +1 more source

A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4. [PDF]

PLoS ONE, 2013
Prostate cancer (PCa) is the second highest cause of cancer death in United States males. If the metastatic movement of PCa cells could be inhibited, then mortality from PCa could be greatly reduced. Mitogen-activated protein kinase kinase 4 (MAP2K4) has
Sankar N Krishna, Chi-Hao Luan, Rama K Mishra, Li Xu, Karl A Scheidt, Wayne F Anderson, Raymond C Bergan   +6 more
doaj   +1 more source

Resolving the binding-kinase discrepancy in bacterial chemotaxis: A nonequilibrium allosteric model and the role of energy dissipation [PDF]

Proc. Natl. Acad. Sci. U.S.A. 120, e2303115120 (2023), 2023
The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the extracellular ligand concentration and adapt across a wide concentration range by undergoing methylation and ...
arxiv   +1 more source