The significance of ERK5 catalytic-independent functions in disease pathways
Frontiers in Cell and Developmental Biology, 2023 Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family.
Nhat-Tu Le
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Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network [PDF]
, 2010 Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of proteins within the cell.
arxiv +1 more source
A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]
arXiv, 2022 The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv
Protein Kinase Cδ Mediates Neurogenic but Not Mitogenic Activation of Mitogen-Activated Protein Kinase in Neuronal Cells [PDF]
Molecular and Cellular Biology, 1999 In several neuronal cell systems, fibroblast-derived growth factor (FGF) and nerve growth factor (NGF) act as neurogenic agents, whereas epidermal growth factor (EGF) acts as a mitogen. The mechanisms responsible for these different cellular fates are unclear.
Marsha Rich Rosner +2 more
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Thrombomodulin Regulation of Mitogen-Activated Protein Kinases [PDF]
International Journal of Molecular Sciences, 2019 The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection, cardiovascular disease, and cancer has been well established. Recently, coagulation factors have also emerged as key players in regulating intracellular signaling pathways during inflammation. Among
Sumith R. Panicker +5 more
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Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. [PDF]
PLoS ONE, 2016 Abnormal survival of retinal pigment epithelium (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR), a sight-threatening disease.
Xiaodong Chen +6 more
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Olea europaea Suppresses Inflammation by Targeting TAK1-Mediated MAP Kinase Activation
Molecules, 2021 Possessing a variety of medicinal functions, Olea europaea L. is widely cultivated across the world. However, the anti-inflammatory mechanism of Olea europaea is not yet fully elucidated.
Chaoran Song, Mi-Yeon Kim, Jae Youl Cho
doaj +1 more source
Mitogen-activated protein kinase cascades in Vitis vinifera
Frontiers in Plant Science, 2015 Protein phosphorylation is one of the most important mechanisms to control cellular functions in response to external and endogenous signals. Mitogen-activated protein kinases (MAPK) are universal signaling molecules in eukaryotes that mediate the ...
Birsen eÇAKIR, Ozan eKılıçkaya
doaj +1 more source
MAP2K4 (mitogen-activated protein kinase kinase 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on MAP2K4 (mitogen-activated protein kinase kinase 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Nakayama, K, Nakayama, N, Miyazaki, K
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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase [PDF]
Journal of Biological Chemistry, 1998 The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements but did not affect genes lacking an AP-1 response element in their promoters.
Frank W. Hobbs +13 more
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