Results 71 to 80 of about 402,236 (378)

Molecular targets of natural health products in arthritis [PDF]

, 2011
Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue of Arthritis Research and Therapy, Haqqi and
Khalifé, Sarah, Zafarullah, Muhammad
core   +2 more sources

Dynamic Ubiquitination of the Mitogen-activated Protein Kinase Kinase (MAPKK) Ste7 Determines Mitogen-activated Protein Kinase (MAPK) Specificity [PDF]

Journal of Biological Chemistry, 2013
Ubiquitination is a post-translational modification that tags proteins for proteasomal degradation. In addition, there is a growing appreciation that ubiquitination can influence protein activity and localization. Ste7 is a prototype MAPKK in yeast that participates in both the pheromone signaling and nutrient deprivation/invasive growth pathways.
Jillian H. Hurst, Henrik G. Dohlman
openaire   +3 more sources

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Journal of Biomedical Science, 2017
Background MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development.
Che-Chung Yeh, Yanying Fan, Yi-Lin Yang, Michael J. Mann   +3 more
doaj   +1 more source

A three-state kinetic mechanism for scaffold mediated signal transduction [PDF]

, 2008
Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert numerous physical effects on signaling pathways. To study these effects, we consider a minimal, three-state kinetic model of scaffold mediated kinase activation.
arxiv   +1 more source

Billion-years old proteins show the importance of N-lobe orientation in Imatinib-kinase selectivity [PDF]

arXiv, 2023
The molecular origins of proteins' functions are a combinatorial search problem in the proteins' sequence space, which requires enormous resources to solve. However, evolution has already solved this optimization problem for us, leaving behind suboptimal solutions along the way. Comparing suboptimal proteins along the evolutionary pathway, or ancestors,
arxiv  

Precision medicine driven by cancer systems biology [PDF]

, 2017
Molecular insights from genome and systems biology are influencing how cancer is diagnosed and treated. We critically evaluate big data challenges in precision medicine.
A Auton, A Barski, A Gros, A Hamosh, A Hauschild, A Kamburov, A Ribas, A Rotte, A Sboner, A Snyder, AD Boiko, AH Ramos, AH Shain, AK Mobley, AL Pritchard, AM Eggermont, AP Bracken, AP Feinberg, AV Danilov, B Obama, B Weide, BA Weir, BC Laurent, BM Carreno, BM Knoppers, C Krepler, C Praetorius, C Robert, C Robert, C Robert, C Robert, C Tokheim, C Zhang, CA Maher, CD Van Raamsdonk, CD Van Raamsdonk, CL Peterson, D Peng, DA Gutman, DA Scott, DG Wang, E Cerami, E Hodis, E Juengst, E Porta-Pardo, E Stronen, E Vire, EA Struys, ED Pleasance, EM Van Allen, EM Verdegaal, ES Lander, F Cruz 3rd, Fabian V. Filipp, FS Hodi, FV Filipp, FV Filipp, FV Filipp, FW Prior, G Bollag, G Chen, G Hatzivassiliou, G Santos, GQ Phan, GR Abecasis, GV Long, H Davies, H Ledford, HB Engin, HC Fan, I Bentwich, J Gao, J Guan, J Larkin, J Larkin, J Tiffen, J Timar, J Yuan, JA Curtin, JA Curtin, JC Tiffen, JC Tiffen, JD Wolchok, KT Flaherty, KT Flaherty, KT Flaherty, L Dang, L Zhang, M Chee, M Krauthammer, MA Postow, MF Berger, MS Lawrence, MS Lawrence, MT Landi, MT McCabe, N McGranahan, N Mitsiades, N Rooij van, N Wagle, NA Rizvi, P Mao, P Natarajan, PB Chapman, PB Hackett, PF Robbins, PM Pollock, R Arafeh, R Beroukhim, R Halaban, R Nazarian, RD Fleischmann, S Bamford, S Kelderman, S Malladi, S Premi, S Reardon, S Turcan, SA Forbes, SB Ng, SI Nikolaev, SJ Aronson, SK Gupta, SQ Wong, T Sjoblom, TA Knijnenburg, TJ Ley, TN Schumacher, W Hugo, W Hugo, WW Overwijk, Y Cheng, Y Khagi, Y Yang, ZA Abdel-Malek   +134 more
core   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

P38 mitogen-activated protein kinase and Parkinson’s disease

Translational Neuroscience, 2018
Parkinson’s disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson’s disease are not fully understood, considerable evidence suggests that neuro-inflammation ...
He Jianying, Zhong Wenwen, Zhang Ming, Zhang Rongping, Hu Weiyan   +4 more
doaj   +1 more source

A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation [PDF]

, 2006
The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model was developed for L-LTP induction in the CA1 region of the hippocampus. The differential equation-based model represents actions of protein kinase A (PKA), MAP kinase (MAPK ...
arxiv   +1 more source