Results 41 to 50 of about 124,344 (344)

Molecular landscape of prostate cancer: implications for current clinical trials. [PDF]

, 2015
Castration-resistant prostate cancer (CRPC) is a lethal disease, and improvement with androgen-deprivation therapy has plateaued. Next-generation sequencing studies have led to significant advances in our understanding of genomic alterations in prostate ...
Ikeda, Sadakatsu, Khemlina, Galina, Kurzrock, Razelle   +2 more
core   +1 more source

Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients

Cancer Medicine, 2015
Mitomycin C (MMC) has potent cytotoxicity but cumulative toxicity limits widespread use. In animals, pegylated liposomal mitomycin C lipid‐based prodrug (PL‐MLP) was well tolerated and more effective than free MMC.
T. Golan, T. Grenader, P. Ohana, Y. Amitay, H. Shmeeda, N. M. La‐Beck, E. Tahover, R. Berger, A. Gabizon   +8 more
semanticscholar   +1 more source

Autophagy and urothelial carcinoma of the bladder: A review. [PDF]

, 2016
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan, Evans, Christopher P   +1 more
core   +2 more sources

Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years

Journal of Ophthalmology, 2015
Purpose. To evaluate the effectiveness and safety of the Ologen as an aid for trabeculectomy performed for primary open-angle glaucoma compared with mitomycin C. Methods. In this prospective, randomized, parallel assignment, comparative study, 31 eyes of
Fei Yuan, Lei Li, Xiuping Chen, Xiang Yan, Li-yang Wang   +4 more
semanticscholar   +1 more source

Phase I study of everolimus and mitomycin C for patients with metastatic esophagogastric adenocarcinoma [PDF]

, 2013
This study aimed at determining the recommended dose of the mammalian target of rapamycin inhibitor everolimus in combination with mitomycin C (MMC) in patients with previously treated metastatic esophagogastric cancer.
Atmaca, Akin, Batran, Salah-Eddin al-, Jäger, Elke, Pauligk, Claudia, Pustowka, Anette, Werner, Dominique   +5 more
core   +1 more source

Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy

Korean Journal of Urology, 2015
Purpose To determine the efficacy of mitomycin C in reducing the recurrence of anterior urethral stricture after internal optical urethrotomy (IOU). Materials and Methods This was a randomized controlled trial conducted in the Department of Urology at ...
L. Ali, Muhammad Shahzad, N. Orakzai, Ihsanullah Khan, Mubashir Ahmad   +4 more
semanticscholar   +1 more source

Simple one-pot fabrication of ultra-stable core-shell superparamagnetic nanoparticles for potential application in drug delivery [PDF]

, 2012
Ultrastable superparamagnetic core-shell nanoparticles of average diameter 80 nm have been fabricated via a simple one-pot method involving superparamagnetic iron oxide nanoparticles (SPIONs) core ([similar]50 nm in diameter) and lipid bilayer shell by ...
Al-Jamal, Allen, Brahler, Bruce, Chetoni, Cheung, De Cuyper, Gabizon, Gaihre, Goodwin, Gupta, Hou, Jarrett, Juliano, Kim, Langer, Laurent, Liu, Mahmoudi, Mahmoudi, Mahmoudi, Mahmoudi, Mahmoudi, Mart, Massart, Meincke, Mezei, Pankhurst, Pauser, Perez, Philipse, Poste, Pradhan, Prozorov, Sasaki, Sen, Sen, Sen, Sharifi, Soenen, Soenen, Tartaj, Tokunaga, Zalipsky   +43 more
core   +1 more source

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]

, 2014
RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Abd Wahab, Akeel A. Mahdi, Al-Deib, Amy L. Upton, Atkinson, Bachmann, Bernhardt, Bolt, Brendler, Briggs, Briggs, Buss, Christian J. Rudolph, Datsenko, David S. Milner, Gari, Geoffrey S. Briggs, Gregg, Gupta, Hong, Jaktaji, Jane I. Grove, Lau, Lecointe, Lesterlin, Lia, Lloyd, Lloyd, Lloyd, Machwe, Mahdi, Mahdi, Mahdi, Mahdi, Manosas, Marians, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, Michel, Parsons, Pomerantz, Ralf, Robert G. Lloyd, Rocha, Rudolph, Rudolph, Rudolph, Rudolph, Seigneur, Sharples, Shereda, Singleton, Sun, Trautinger, Tsaneva, Vincent, Waldminghaus, West, Whitby, Whitby, Whitby, Whitby, Zacharias, Zhang   +68 more
core   +2 more sources

Tissue typing by unidirectional mixed lymphocyte culture. 3. The relationship of in vitro lymphocyte compatibility to renal allograft rejection [PDF]

, 1971
We applied unidirectional MLC test to renal allograft in dogs, and investigated the correlation between the growth rates of MLC reaction and the intensity of rejection of the kidney transplants or the postoperative renal function.
Tsunemitsu, Kensuke
core   +1 more source

Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin.

Journal of Clinical Oncology, 2012
PURPOSE On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study of 5-Fluorouracil (5-FU), Mitomycin, and Radiotherapy Versus 5-Fluorouracil, Cisplatin and Radiotherapy in Carcinoma of the Anal ...
L. Gunderson, K. Winter, J. Ajani, J. Pedersen, J. Moughan, A. Benson, Charles R. Thomas, R. Mayer, M. Haddock, T. Rich, C. Willett   +10 more
semanticscholar   +1 more source