Results 81 to 90 of about 85,416 (247)

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis

International Archives of Otorhinolaryngology, 2020
Introduction Mitomycin C is a natural antibiotic that has been used to inhibit the proliferation of fibroblasts in scar tissue. Objective To evaluate the effectiveness and safety of topical Mitomycin C as an adjuvant in the endoscopic ...
Thereza L. O. Queiroga, Daniele C. Cataneo, Regina H. G. Martins, Tarcisio A. Reis, Antônio J. M. Cataneo   +4 more
doaj   +1 more source

Tuberculosis vaccine strain _Mycobacterium bovis_ BCG Russia is a natural _recA_ mutant [PDF]

, 2008
The current tuberculosis vaccine is a live vaccine derived from _Mycobacterium bovis_ and attenuated by serial _in vitro_ passaging. All vaccine substrains in use stem from one source, strain Bacille Calmette-Guérin.
Erik C. Boettger, Peter M. Keller, Peter Sander   +2 more
core   +1 more source

Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes [PDF]

, 2014
The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present
Barrón-Vivanco, Briscia S., Benitez-Trinidad, alma B., González Arias, Cyndia A., Marín Sillué, Sònia, Medina-Díaz, Irma M., Ramos Girona, Antonio J., Robledo-Marenco, Lourdes, Rojas-García, A. E., Sanchís Almenar, Vicente, Sordo, Montserrat   +9 more
core   +2 more sources

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

The Protective Effect of Silibinin Against Mitomycin C–Induced Intrinsic Apoptosis in Human Melanoma A375-S2 Cells

Journal of Pharmacological Sciences, 2009
Silibinin is known for its hepatoprotective, anti-inflammatory, and anti-carcinogenic effects. We found that silibinin exhibited a protective effect against chemotherapeutic reagent mitomycin C–induced cell death in A375-S2 cells in a p53-dependent ...
Yuan-yuan Jiang, Hong-jun Wang, Jing Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima   +5 more
doaj   +1 more source

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2013
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Imamovic, Lejla, Muniesa Pérez, Ma Teresa   +1 more
core   +2 more sources

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Efficacy of adjuvant mitomycin-C and triamcinolone-impregnated nasal packing for endoscopic dacryocystorhinostomy [PDF]

International Journal of Ophthalmology
AIM: To compare the success rate and complications of adjuvant use of mitomycin C and triamcinolone- impregnated biodegradable nasal packing (TABP) in endoscopic dacryocystorhinostomy (DCR).
Sang Yoon Kim, Christopher B Chambers, Jung Hyo Ahn   +2 more
doaj   +1 more source

Metabolomic evaluation of Mitomycin C and rapamycin in a personalized treatment of pancreatic cancer [PDF]

, 2014
In a personalized treatment designed for a patient with pancreatic cancer resistant to other treatments, the success of Mitomycin C (MMC) has been highlighted.
Armitage, Emily G., Barbas, Coral, Bujak, Renata, García, Antonia, Hidalgo, Manuel, López-Casas, Pedro P., Mastrangelo, Annalaura, Musteanu, Monica, Navarrete, Alicia   +8 more
core   +1 more source