Results 81 to 90 of about 124,344 (344)

Mitomycin-C: 'a ray of hope' in refractory corrosive esophageal strictures.

Diseases of the esophagus, 2014
Increasingly frequent dilation may become a self-defeating cycle in refractory stricture as recurrent trauma enhance, scar formation, and ultimately recurrence and potential worsening of the stricture.
Neeraj Nagaich, S. Nijhawan, P. Katiyar, Radha Sharma, M. Rathore   +4 more
semanticscholar   +1 more source

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

BioEssays, EarlyView.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source

No effects of mitomycin-C in primary trabeculectomies in Sweden

SAGE Open Medicine, 2018
Aim: To evaluate the results of a long-term follow-up after two different types of surgical techniques: trabeculectomy with or without mitomycin-C. Materials and methods: This study is a retrospective chart review of patients operated on with a primary ...
Marcelo Ayala
doaj   +1 more source

Interventions for the treatment of oral cavity and oropharyngeal cancer:chemotherapy [PDF]

, 2010
<b>Background:</b> Oral cavity and oropharyngeal cancers are frequently described as part of a group of oral cancers or head and neck cancer. Treatment of oral cavity cancer is generally surgery followed by radiotherapy, whereas oropharyngeal
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core   +6 more sources

Mitomycin C in ophthalmology

Journal of the Scientific Society, 2012
Introduction to the use of Mitomycin C in ophthalmology was a significant development in the 1960s. Its use and application in ophthalmology has been increasing in recent years, because of its modulatory effects on wound healing. Current applications of this drug in ophthalmology include pterygium surgery, glaucoma surgery, corneal refractive surgery ...
R. S. Mudhol, Rekha Mudhol, N. D. Zingade   +2 more
openaire   +3 more sources

Synthesis and Evaluation of Trehalose‐Based Mertansine Warheads for Bacillus Calmette–Guérin Delivery of Anticancer Agents

ChemBioChem, EarlyView.
Bacillus Calmette–Guérin (BCG) immunotherapy is the gold standard for nonmuscle invasive bladder cancer (NMIBC). However, it is limited by adverse effects and resistance, despite eliciting a robust immune response. This proof‐of‐concept study explores Antigen 85‐mediated, metabolically with trehalose‐PEG4 mertansine‐labeled BCG as a novel treatment ...
Michael Grimmeisen, Xuan Wang, Melissa Weldle, Kerstin Sartory, Sara Benkhelifa, Yu Zhang, Trinh Dao, Jonas Meyer, Oliver Gorka, Olaf Groß, Claudia Jessen‐Trefzer   +10 more
wiley   +1 more source

Mitomycin C induces apoptosis in human epidural scar fibroblasts after surgical decompression for spinal cord injury

Neural Regeneration Research, 2017
Numerous studies have shown that topical application of mitomycin C after surgical decompression effectively reduces scar adhesion. However, the underlying mechanisms remain unclear.
Tao Sui, Da-wei Ge, Lei Yang, Jian Tang, Xiao-jian Cao, Ying-bin Ge   +5 more
doaj   +1 more source

UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells [PDF]

, 2012
The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons.
An, JY, de Rooij, DG, Han, DH, Jang, JM, Kim, BY, Kim, E, Kim, TY, Kwon, YT, Lee, MJ, Lee, YJ, Seo, JW, Yoo, YD, Zakrzewska, A   +12 more
core   +1 more source

Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish

Developmental Dynamics, EarlyView.
Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan, Travis K. Johnson, Zachary Di Pastena, Jarrad N. Fuller, Lee B. Miles, Sebastian Dworkin   +5 more
wiley   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source