Actin cables and comet tails organize mitochondrial networks in mitosis
Nature, 2021 Symmetric cell division requires the even partitioning of genetic information and cytoplasmic contents between daughter cells. Whereas the mechanisms coordinating the segregation of the genome are well known, the processes that ensure organelle ...
Andrew S Moore +2 more
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Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Science, 2021 Keeping cGAS silent Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin ...
Tuo Li, Tuozhi Huang, Mingjian Du
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Optical volume and mass measurements show that mammalian cells swell during mitosis [PDF]
Journal of Cell Biology, 2015 Mammalian cells display a significant increase in volume during mitosis, which corresponds to a decrease in cell density, is linked to the mitotic state and not to the cell shape, and is independent of the actomyosin cortex.
Ewa Zlotek-Zlotkiewicz +4 more
openalex +2 more sources
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Nature, 2019 Features of higher-order chromatin organization—such as A/B compartments, topologically associating domains and chromatin loops—are temporarily disrupted during mitosis1,2.
Haoyue Zhang +2 more
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DNA breaks and chromosome pulverization from errors in mitosis
Nature, 2012 The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA
Karen Crasta, Neil J Ganem, Luigi Nezi
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A changing paradigm of transcriptional memory propagation through mitosis
Nature Reviews Molecular Cell Biology, 2018 Katherine C Palozola +2 more
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The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
Nature Reviews Molecular Cell Biology, 2012 Mar Carmena, Hironori Funabiki
exaly +2 more sources
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
Nature Reviews Molecular Cell Biology, 2015 Sushama Sivakumar, Gary J Gorbsky
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Whole-Slide Mitosis Detection in H&E Breast Histology Using PHH3 as a Reference to Train Distilled Stain-Invariant Convolutional Networks [PDF]
IEEE Transactions on Medical Imaging, 2018 Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone.
David Tellez +12 more
semanticscholar +1 more source
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis
Science Signaling, 2018 Precise spatiotemporal control enables the mitotic kinases Aurora and PLK1 to orchestrate distinct mitotic processes. Gloss Ever since its first observation under the microscope over a century ago, mitosis—the process wherein a cell divides into two ...
V. Joukov, A. De Nicolo
semanticscholar +1 more source