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Mitosis detection in histopathological images using customized deep learning and hybrid optimization algorithms. [PDF]
PLoS ONEIdentifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Afnan M Alhassan, Nouf I Altmami
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Emerging Roles for Transcription Factors During Mitosis [PDF]
CellsThe genome is dynamically reorganized, partitioned, and divided during mitosis. Despite their role in organizing interphase chromatin, transcription factors were largely believed to be mitotic spectators evicted from chromatin during mitosis, only able ...
Samuel Flashner, Jane Azizkhan-Clifford
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Preparation for mitosis requires gradual CDK1 activation [PDF]
iScienceSummary: G2 phase is considered as a time in which cells prepare for the large structural changes in the following mitosis. Starting at completion of DNA replication, CDK1 and PLK1 kinase activities gradually increase throughout G2 phase until reaching ...
Karen Akopyan, Zhiyu Hao, Arne Lindqvist
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Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]
PLoS ONE, 2011 Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar +4 more
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Contextual Prior Constrained Deep Networks for Mitosis Detection With Point Annotations
IEEE Access, 2021 We study the problem of training an accurate deep learning mitosis detection model with only point annotations. To address this challenging label-efficient deep learning problem, we propose a novel contextual prior constraint mechanism and spatial area ...
Jiangxiao Han, Xinggang Wang, Wenyu Liu
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Turning end-joining upside down in mitosis
Molecular & Cellular Oncology, 2021 How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions.
Marta Llorens-Agost +4 more
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Anti-tumor pharmacology of natural products targeting mitosis
Cancer Biology & Medicine, 2022 Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis.
Manru Huang +7 more
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SmallMitosis: Small Size Mitotic Cells Detection in Breast Histopathology Images
IEEE Access, 2021 Mitotic figure count acts as a proliferative marker to measure aggressiveness of the breast cancer tumor. In this article, we have proposed a novel framework named SmallMitosis to detect mitotic cells particularly very small size mitosis from hematoxylin
Tasleem Kausar +3 more
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Data in Brief, 2017 In this article, we present the data related to motivational factors given by the medical (n=118) and nursing (n=217) staff, of a Greek Public General Hospital during a period of financial austerity.
Marianna Charalambous +2 more
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Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events [PDF]
, 2016 Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is ...
Araujo, AR +3 more
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