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SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle.
Ducháček, Ladislav
openaire +4 more sources
Emerging Roles for Transcription Factors During Mitosis [PDF]
The genome is dynamically reorganized, partitioned, and divided during mitosis. Despite their role in organizing interphase chromatin, transcription factors were largely believed to be mitotic spectators evicted from chromatin during mitosis, only able ...
Samuel Flashner, Jane Azizkhan-Clifford
doaj +2 more sources
Mitosis recursion for coefficients of Schubert polynomials [PDF]
Mitosis is a rule introduced by [Knutson-Miller, 2002] for manipulating subsets of the n by n grid. It provides an algorithm that lists the reduced pipe dreams (also known as rc-graphs) [Fomin-Kirillov, Bergeron-Billey] for a permutation w in S_n by downward induction on weak Bruhat order, thereby generating the coefficients of Schubert polynomials ...
Miller, Ezra
arxiv +6 more sources
Chromosome Oscillations in Mitosis [PDF]
http://hogarth.pct.espci.fr/~pierre/
Campàs, Otger, Sens, Pierre
openaire +7 more sources
Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells. [PDF]
Stem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly ...
Eric Cheng, Ran Lu, Abigail R Gerhold
doaj +2 more sources
Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes [PDF]
Nuclear lipids play roles in regulatory processes, such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis.
Hsiao-Tang Hu+4 more
doaj +2 more sources
Turning end-joining upside down in mitosis
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions.
Marta Llorens-Agost+4 more
doaj +1 more source
Contextual Prior Constrained Deep Networks for Mitosis Detection With Point Annotations
We study the problem of training an accurate deep learning mitosis detection model with only point annotations. To address this challenging label-efficient deep learning problem, we propose a novel contextual prior constraint mechanism and spatial area ...
Jiangxiao Han, Xinggang Wang, Wenyu Liu
doaj +1 more source
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]
Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar+4 more
doaj +1 more source
Anti-tumor pharmacology of natural products targeting mitosis
Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis.
Manru Huang+7 more
doaj +1 more source