Results 1 to 10 of about 386,071 (373)
Cold Spring Harbor Perspectives in Biology, 2016 SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle.
Ducháček, Ladislav
core +5 more sources
FEBS Letters, 2019 Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This simple reaction rapidly and irreversibly sets the cell up for division. Even though the core step in triggering mitosis is so simple, the regulation of this cellular switch is highly complex, involving a large number of interconnected signalling cascades.
Adrijana Crncec, Helfrid Hochegger
openaire +3 more sources
Mitosis detection in histopathological images using customized deep learning and hybrid optimization algorithms. [PDF]
PLoS ONEIdentifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Afnan M Alhassan, Nouf I Altmami
doaj +2 more sources
Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis. [PDF]
ElifeCai X +6 more
europepmc +2 more sources
Contextual Prior Constrained Deep Networks for Mitosis Detection With Point Annotations
IEEE Access, 2021 We study the problem of training an accurate deep learning mitosis detection model with only point annotations. To address this challenging label-efficient deep learning problem, we propose a novel contextual prior constraint mechanism and spatial area ...
Jiangxiao Han, Xinggang Wang, Wenyu Liu
doaj +1 more source
Turning end-joining upside down in mitosis
Molecular & Cellular Oncology, 2021 How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions.
Marta Llorens-Agost +4 more
doaj +1 more source
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]
PLoS ONE, 2011 Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar +4 more
doaj +1 more source
Anti-tumor pharmacology of natural products targeting mitosis
Cancer Biology & Medicine, 2022 Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis.
Manru Huang +7 more
doaj +1 more source
SmallMitosis: Small Size Mitotic Cells Detection in Breast Histopathology Images
IEEE Access, 2021 Mitotic figure count acts as a proliferative marker to measure aggressiveness of the breast cancer tumor. In this article, we have proposed a novel framework named SmallMitosis to detect mitotic cells particularly very small size mitosis from hematoxylin
Tasleem Kausar +3 more
doaj +1 more source