Results 1 to 10 of about 380,556 (390)
Cold Spring Harbor Perspectives in Biology, 2016 SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle.
J. McIntosh
semanticscholar +5 more sources
Actin cables and comet tails organize mitochondrial networks in mitosis
Nature, 2021 Symmetric cell division requires the even partitioning of genetic information and cytoplasmic contents between daughter cells. Whereas the mechanisms coordinating the segregation of the genome are well known, the processes that ensure organelle ...
Andrew S Moore +2 more
exaly +2 more sources
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Science, 2021 Keeping cGAS silent Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin ...
Tuo Li, Tuozhi Huang, Mingjian Du
exaly +2 more sources
Mitosis detection in histopathological images using customized deep learning and hybrid optimization algorithms. [PDF]
PLoS ONEIdentifying mitosis is crucial for cancer diagnosis, but accurate detection remains difficult because of class imbalance and complex morphological variations in histopathological images.
Afnan M Alhassan, Nouf I Altmami
doaj +2 more sources
FEBS Letters, 2019 Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This simple reaction rapidly and irreversibly sets the cell up for division.
Adrijana Crncec, H. Hochegger
semanticscholar +3 more sources
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Nature, 2019 Features of higher-order chromatin organization—such as A/B compartments, topologically associating domains and chromatin loops—are temporarily disrupted during mitosis1,2.
Haoyue Zhang +2 more
exaly +2 more sources
Mitosis Counting in Breast Cancer: Object-Level Interobserver Agreement and Comparison to an Automatic Method. [PDF]
PLoS ONE, 2016 Tumor proliferation speed, most commonly assessed by counting of mitotic figures in histological slide preparations, is an important biomarker for breast cancer.
Mitko Veta +4 more
doaj +2 more sources
eLife, 2016 Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
Chii Shyang Fong +7 more
doaj +2 more sources
DNA breaks and chromosome pulverization from errors in mitosis
Nature, 2012 The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA
Karen Crasta, Neil J Ganem, Luigi Nezi
exaly +2 more sources
Regulation of mRNA translation during mitosis
eLife, 2015 Passage through mitosis is driven by precisely-timed changes in transcriptional regulation and protein degradation. However, the importance of translational regulation during mitosis remains poorly understood. Here, using ribosome profiling, we find both
Marvin E Tanenbaum +3 more
doaj +2 more sources