Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells. [PDF]
PLoS GeneticsStem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly ...
Eric Cheng, Ran Lu, Abigail R Gerhold
doaj +2 more sources
Mitosis Counting in Breast Cancer: Object-Level Interobserver Agreement and Comparison to an Automatic Method. [PDF]
PLoS ONE, 2016 Tumor proliferation speed, most commonly assessed by counting of mitotic figures in histological slide preparations, is an important biomarker for breast cancer.
Mitko Veta +4 more
doaj +2 more sources
eLife, 2016 Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
Chii Shyang Fong +7 more
doaj +2 more sources
Mitosis Detection in Breast Cancer Histology Images via Deep Cascaded Networks
Proceedings of the AAAI Conference on Artificial Intelligence, 2016 The number of mitoses per tissue area gives an important aggressiveness indication of the invasive breast carcinoma.However, automatic mitosis detection in histology images remains a challenging problem. Traditional methods either employ hand-crafted
Hao Chen +4 more
exaly +2 more sources
Regulation of mRNA translation during mitosis
eLife, 2015 Passage through mitosis is driven by precisely-timed changes in transcriptional regulation and protein degradation. However, the importance of translational regulation during mitosis remains poorly understood. Here, using ribosome profiling, we find both
Marvin E Tanenbaum +3 more
doaj +2 more sources
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Nature, 2019 Belinda Giardine +2 more
exaly +2 more sources
Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis
Nature, 2016 Floris Bosveld +2 more
exaly +2 more sources
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
Nature Reviews Molecular Cell Biology, 2012 Mar Carmena +2 more
exaly +2 more sources
Phosphorylation and Chromatin Tethering Prevent cGAS activation During Mitosis
Science, 2021 Keeping cGAS silent Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin ...
Tuo Li +6 more
semanticscholar +1 more source
Contextual Prior Constrained Deep Networks for Mitosis Detection With Point Annotations
IEEE Access, 2021 We study the problem of training an accurate deep learning mitosis detection model with only point annotations. To address this challenging label-efficient deep learning problem, we propose a novel contextual prior constraint mechanism and spatial area ...
Jiangxiao Han, Xinggang Wang, Wenyu Liu
doaj +1 more source