Results 71 to 80 of about 4,840,174 (316)

Cell Segmentation, Tracking, and Mitosis Detection Using Temporal Context [PDF]

, 2005
The Large Scale Digital Cell Analysis System (LSDCAS) developed at the University of Iowa provides capabilities for extended-time live cell image acquisition. This paper presents a new approach to quantitative analysis of live cell image data. By using time as an extra dimension, level set methods are employed to determine cell trajectories from 2D ...
Fuxing, Yang, Michael A, Mackey, Fiorenza, Ianzini, Greg, Gallardo, Milan, Sonka   +4 more
openaire   +2 more sources

Mitosis sequence detection using hidden conditional random fields [PDF]

2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010
We propose a fully-automated mitosis event detector using hidden conditional random fields for cell populations imaged with time-lapse phase contrast microscopy. The method consists of two stages that jointly optimize recall and precision. First, we apply model-based microscopy image preconditioning and volumetric segmentation to identify candidate ...
A-A Liu, K. Li, T. Kanade
openaire   +1 more source

The role of the cell cycle machinery in resumption of postembryonic development [PDF]

, 2005
Cell cycle activity is required for plant growth and development, but its involvement in the early events that initiate seedling development remains to be clarified. We performed experiments aimed at understanding when cell cycle progression is activated
Barrôco, Rosa Maria, Van Poucke, Kris, Bergervoet, Jan HW, De Veylder, Lieven, Groot, Steven PC, Inzé, Dirk, Engler, Gilbert   +6 more
core   +2 more sources

Effect of Mitosis on the Resistance to Oxidative and Osmotic Stresses in Yeast

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2020
Cancercells are defined by abnormal and unrestricted mitotic divisions, thereforetargeting mitosis is a useful strategy for cancer treatment. Two groups ofdrugs that are most successfully used in the treatment of several types ofcancer, taxanes and ...
Pinar Buket Atalay, Nur Kaluc, Elif Ergin Cavusoglu   +2 more
doaj   +1 more source

Association of p60c-src with endosomal membranes in mammalian fibroblasts. [PDF]

, 1992
We have examined the subcellular localization of p60c-src in mammalian fibroblasts. Analysis of indirect immunofluorescence by three-dimensional optical sectioning microscopy revealed a granular cytoplasmic staining that co-localized with the microtubule
Kaplan, KB, Morgan, DO, Swedlow, JR, Varmus, HE   +3 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Mitosis Detection using YOLOv5 and EfficientNet

, 2023
To accurately assess the prognosis of various tumors, mitosis de- tection plays a crucial role. The objective of the MIDOG 2022 MICCAI challenge is to develop approaches that are indepen- dent of tissue-related domain shifts and tissue types. We pro- pose a two-stage mitosis detection system, utilizing YOLOv5 as the candidate mitosis generator and ...
openaire   +1 more source

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]

, 2013
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead, Bonneau, Bradley, Bushell, Byrd, Carmena, Clemens, Coldwell, Coldwell, Coldwell, Dobrikov, Elia, Fadden, Fan, Franz-Wachtel, Gingras, Gingras, Gradi, Harrison, Heesom, Heesom, Hinton, Jackson, Jang, Joanne Cowan, Kim, Laplante, Lisa Perry, Ma, Margalit, Marissen, Mark Coldwell, Mark Willett, Markete Vlasak, Morley, Morris, Nagano, Pasquier, Perez, Proud, Pyronnet, Pyronnet, Qin, Qin, Shevchenko, Simon Morley, Singh, Skop, Smith, Sonenberg, Tinton, Vassilev, Wek, Whitfield, Wurzenberger, Xue   +55 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Meiotic progression in arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM [PDF]

, 2010
International audienceMeiosis is a modified cell division that produces four haploid nuclei from a single diploid cell in two rounds of chromosome segregation.
Bulankova, Petra, Riehs-Kearnan, Nina, Nowack, Moritz, Schnittger, Arp, Riha, Karel   +4 more
core   +3 more sources