Results 71 to 80 of about 91,818 (255)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
, 2019 In the present investigation the effect of the different Chemical and Physical mutagens like EMS, Gamma rays and combination of both EMS and Gamma rays concentration and doses were studied for the mitotic index and mitotic abnormalities in the ...
Jagtap, S. S.; Assistant Professor, Department of Botany, Waghire College, Saswad, Pune +1 more
core
Validation of a Mitotic Index Cutoff as a Prognostic Marker in Undifferentiated Uterine Sarcomas
, 2017 Undifferentiated uterine sarcomas (UUS) are a heterogenous group of high-grade mesenchymal tumors. Although these tumors are highly aggressive, a subset of patients may experience long-term survival.
Elin Hardell +33 more
core +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
In vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood lymphocytes
Bangladesh Journal of Pharmacology, 2012 Hypericum species have been used in traditional medicine in Turkey for thousands of years. In order to determine the cytogenetic effects of Hypericum heterophyllum, human lymphocytes were incubated with the aqueous extracts. Mitotic index frequencies and
Afide Öcal, Halil Erhan Eroğlu
doaj +1 more source
Suprabasal mitotic index: A cell kinetic aid in psoriasis diagnosis
, 2017 Background: Psoriatic cell kinetic studies attribute psoriatic hyperplasia to increased germinative cell layer and increased mitotic rate causing rapid cell turnover, resulting in suprabasal mitotic activity.
Susan Maria Mendonca, Sumanth Devaraju
core +1 more source
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
, 2010 Morphometry [nuclear Ki-67 labelling, mitotic activity index (MI), and volume-corrected mitotic index (M/V)] for periampullary cancers using tissue microarrays has not been performed previously.
Mark M. Aloysius (9149495) +5 more
core +1 more source
Advanced Science, EarlyView.In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin +13 more
wiley +1 more source
, 2017 Background: In India, cervical cancer ranks as the 2nd most frequent cancer among women. This study was carried out to study the role of apoptotic index (AI), mitotic index (MI) and MIB-1 labelling index (LI) as biomarkers in preneoplastic and neoplastic
Verma, Nidhi +4 more
core +1 more source