Comparison of apoptotic bodies' count & mitotic index in oral squamous cell carcinoma with regional lymph node involvement. [PDF]
Indian J Med Res, 2023 Yousefi M, Naderi NJ, Muhammadnejad A.
europepmc +1 more source
Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution
Advanced Science, EarlyView.This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida +4 more
wiley +1 more source
Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone. [PDF]
Vet Sci, 2022 Ng KWL, Beatty JA, Tse MPY, Giuliano A.
europepmc +1 more source
Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Растениевъдни науки, 2020 The effects of glutamine on the seed germination, seedling growth (radicle lenght, radicle number and fresh weight), mitotic index and chromosome aberrations of Allium cepa L. germinated under saline conditions were examined in this study.
Kürşat Çavuşoğlu +2 more
doaj
Deep learning and radiomics to predict the mitotic index of gastrointestinal stromal tumors based on multiparametric MRI. [PDF]
Front Oncol, 2022 Yang L +9 more
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Advanced Science, EarlyView.Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo +14 more
wiley +1 more source
The Effect of Voltarin Drug on Some Genetic Indices in Albino Mice
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 The present study is designed to reveal the effect of Voltarin drug on some genetic indicators such as mitotic index(MI) of bone marrow cells and chromosome aberrations(CA) .The Voltarin is one of non Steroidal Anti-inflammation drug .Three ...
F. A. Hadi, K. S. Nasir
doaj
Atypical meningiomas with an immunohistochemical profile consistent with hypermetabolic or proliferative molecular groups show high mitotic index, chromosomal instability, and higher recurrence risk. [PDF]
Virchows Arch, 2023 Barresi V +5 more
europepmc +1 more source
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
Advanced Science, EarlyView.The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao +11 more
wiley +1 more source