From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Studies on the phase I and II metabolism and the toxicological analysis of the alkaloids of the herbal drug of abuse Mitragyna speciosa Korth. (Kratom) using gas chromatography-mass spectrometry and liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry [PDF]
, 2011 In the presented studies, the herbal drug Kratom (Mitragyna speciosa) was investigated regarding its metabolism and its toxicological analysis in rat and human urine.
Philipp, Anika-Anina
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Kratom: The analytical challenge of an emerging herbal drug [PDF]
, 2023 Mitragyna speciosa or kratom is emerging worldwide as a “legal” herbal drug of abuse. An increasing number of papers is appearing in the scientific literature regarding its pharmacological profile and the analysis of its chemical constituents, mainly ...
Cannazza G. +4 more
core +1 more source
Sociology Compass, Volume 19, Issue 3, March 2025.ABSTRACT The concept of cultural appropriation has drawn increasing attention from academic disciplines and nonacademic circles. Yet, there is no consensus on what constitutes cultural appropriation nor whether it is harmful. The contested nature of the concept suggests that it is important to understand how people respond to such accusations.
Heith Copes +4 more
wiley +1 more source
Drogas legales emergentes: marihuana sintética, kratom, salvia divinorum, metoxetamina y los derivados de la piperazina [PDF]
, 2015 A pesar de su amplia oferta y disponibilidad a través de internet, muchas de las drogas de abuso emergentes siguen siendo desconocidas para un gran número de médicos y profesionales sanitarios.
Aliño, Marta +4 more
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Scientifica, Volume 2025, Issue 1, 2025.Natural healthcare products with antiaging properties are attracting growing interest, and Thailand has a rich tradition of using herbal remedies for disease treatment and overall well‐being. Mitra tea, derived from the traditional Mitratonic Remedy, is a Thai herbal formulation that has been used by local traditional healers for over 20 years and is ...
Acharaporn Issuriya +5 more
wiley +1 more source
Effect of short-term ingestion of the methanolic extract of mitragyna speciosa on sperm quality in mice [PDF]
, 2011 Mitragyna speciosa (MS) which is known as “Ketum” in Malaysia and “Kratom” in Thailand is a tropical plant indigenous to Southeast Asia. The leaves of MS have been used by natives of these countries for their opium-like effects and cocaine-like ...
Abdul Kadir, Arifah +3 more
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A case of fatal overdose involving both hydromorphone and kratom
Journal of Forensic Sciences, Volume 69, Issue 1, Page 355-358, January 2024.Abstract Kratom is a plant originating in Southeast Asia that has been used for its dose‐dependent stimulant and opioid effects. The main active compound in kratom is mitragynine, an alkaloid with affinity for the mu‐opioid receptor. Toxicity and fatalities related to kratom use have increased substantially in recent years.
Thomas Shi, Jennifer L. Shea
wiley +1 more source
Uji Efek Sedatif Fraksi Etanol Daun Kratom (Mitragyna Speciosa Korth.) Pada Mencit Jantan Galur Balb/c [PDF]
, 2013 Kratom (Mitragyna speciosa Korth.) is one of traditional medical plant that canproduces both stimulant effects (in low doses) and sedative effects (in high doses).
Ridayani, Y. (Yeni)
core +1 more source
Kratom (Mitragyna speciosa): ¿droga emergente o bala mágica? [PDF]
, 2013 En los últimos años, un número indeterminado y creciente de sustancias con actividad psicotrópica están siendo introducidas en contextos recreativos a través del mercado tecnológico que suponen internet y las nuevas tecnologías, tratando de franquear ...
Giner García, Ricardo +1 more
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