Results 121 to 130 of about 6,245 (294)

Development of Real-Time and Mixed Criticality Distributed Systems through the DDS Standard

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2018
The use of distribution middleware facilitates the programming of heterogeneous real-time distributed systems, and it can also facilitate the automatic generation of source code when integrated as a part of a general MDE (Model-Driven Engineering ...
Héctor Pérez Tijero, J. Javier Gutiérrez   +1 more
doaj   +1 more source

A toolset for the development of mixed-criticality partitioned systems [PDF]

, 2014
The development of mixed-criticality virtualized multi-core systems poses new challenges that are being subject of active research work. There is an additional complexity: it is now required to identify a set of partitions, and allocate applications to ...
Alonso Muñoz, Alejandro Antonio, Miguel Cabello, Miguel Angel de, Salazar Marsá, José Emilio   +2 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Enhancing Performance in Mixed‐Criticality Real‐Time Systems Through Learner‐Based Resource Management

IET Cyber-Physical Systems
In mixed‐criticality (MC) systems, tasks with varying criticality levels share resources, leading to challenges in resource management during mode transitions.
Mohammadreza Saberikia, Hakem Beitollahi, Rasool Jader, Hamed Farbeh   +3 more
doaj   +1 more source

Hypervisor-Based Multicore Feedback Control of Mixed-Criticality Systems

IEEE Access, 2018
One of the most promising approaches to mixed-criticality systems is the use of multi-core execution platforms based on a hypervisor. Several successful EU Projects are based on this approach and have overcome some of the difficulties that this approach ...
Alfons Crespo, Patricia Balbastre, Jose Simo, Javier Coronel, Daniel Gracia-Perez, Philippe Bonnot   +5 more
doaj   +1 more source

Towards model-driven engineering for mixed-criticality systems: multiPARTES approach [PDF]

, 2013
Mixed criticality systems emerges as a suitable solution for dealing with the complexity, performance and costs of future embedded and dependable systems. However, this paradigm adds additional complexity to their development.
Alonso Muñoz, Alejandro Antonio, Grepet, Cyril, Jouvray, Christophe, Miguel Cabello, Miguel Angel de, Simó, José, Trujillo González, Salvador   +5 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source