Results 81 to 90 of about 54,269 (293)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Response Time Analysis for Mixed Criticality Systems with Arbitrary Deadlines [PDF]

, 2017
This paper extends analysis of the Adaptive Mixed Criticality (AMC) scheme for fixed-priority preemptive scheduling of mixed-criticality systems to include tasks with arbitrary deadlines. Both of the previously published schedulability tests, AMC-rtb and
Burns, Alan, Davis, Robert Ian
core  

Relaxing the synchronous approach for mixed-criticality systems

2014 IEEE 19th Real-Time and Embedded Technology and Applications Symposium (RTAS), 2014
Synchronous languages are widely used to design safety-critical embedded systems. These languages are based on the synchrony hypothesis, asserting that all tasks must complete instantaneously at each logical time step. This assertion is, however, unsuitable for the design of mixed-criticality systems, where some tasks can tolerate missed deadlines ...
Yip, Eugene, Kuo, Matthew M Y, Roop, Partha S, Broman, David   +3 more
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Mixed criticality systems with weakly-hard constraints [PDF]

Proceedings of the 23rd International Conference on Real Time and Networks Systems, 2015
Current adaptive mixed criticality scheduling policies assume a high criticality mode in which all low criticality tasks are descheduled to ensure that high criticality tasks can meet timing constraints derived from certification approved methods. In this paper we present a new scheduling policy, Adaptive Mixed Criticality - Weakly Hard, which provides
Gettings, Oliver, Quinton, Sophie, Davis, Robert   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Architecture design for distributed mixed-criticality systems based on multi-core chips [PDF]

, 2017
In vielen Anwendungsbereichen wie beispielsweise der Avionik, industriellen Kontrollsystemen und dem Gesundheitswesen gewinnen sogenannte Mixed-Criticality Systeme, in denen Anwendungen mit unterschiedlicher Wichtigkeit sowie unterschiedlichen ...
Abuteir, Mohammed
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mixed Criticality Multicore Compositional Framework

IEEE Access
In the field of real-time systems, component-based models for mixed criticality systems (MCS) on multicore platform are gaining significant attention of the researchers from the recent past.
Amjad Ali, Imran Taj, Shahid Iqbal, Muhammad Fayaz, Asad Masood Khattak, Bashir Hayat   +5 more
doaj   +1 more source

Development of Real-Time and Mixed Criticality Distributed Systems through the DDS Standard

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2018
The use of distribution middleware facilitates the programming of heterogeneous real-time distributed systems, and it can also facilitate the automatic generation of source code when integrated as a part of a general MDE (Model-Driven Engineering ...
Héctor Pérez Tijero, J. Javier Gutiérrez   +1 more
doaj   +1 more source