Results 81 to 90 of about 10,725,281 (282)

Development of Real-Time and Mixed Criticality Distributed Systems through the DDS Standard

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2018
The use of distribution middleware facilitates the programming of heterogeneous real-time distributed systems, and it can also facilitate the automatic generation of source code when integrated as a part of a general MDE (Model-Driven Engineering ...
Héctor Pérez Tijero, J. Javier Gutiérrez   +1 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Schedulability Analysis of Mixed-Criticality Systems on Multiprocessors

, 2012
The advent of multicore processors has attracted many safety-critical systems, e.g., automotive and avionics, to consider integrating multiple functionalities on a single, powerful computing platform.
Pathan, Risat, Risat Mahmud Pathan, Pathan, Risat Mahmud, Pathan, Risat,   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Modeling Mixed-critical Systems in Real-time BIP

, 2013
International audienceThe proliferation of multi- and manycores creates an important design problem: the design and verification for mixed-criticality constraints in timing and safety, taking into account the resource sharing and hardware faults.
Bozga, Marius, Poplavko, Peter, Bensalem, Saddek, Socci, Dario   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Providing spatial isolation for Mixed-Criticality Systems

, 2022
reservedThis work is situated in the domain of hard real-time systems subject to stringer timing constraints, which find industrial applications in many safety-critical sectors, such as the avionics and space.
TINTO, EDOARDO
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A toolset for the development of mixed-criticality partitioned systems [PDF]

, 2014
The development of mixed-criticality virtualized multi-core systems poses new challenges that are being subject of active research work. There is an additional complexity: it is now required to identify a set of partitions, and allocate applications to ...
Salazar Marsá, José Emilio, Alonso Muñoz, Alejandro Antonio, Miguel Cabello, Miguel Ángel de   +2 more
core   +1 more source