Results 61 to 70 of about 184,542 (302)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
On Mixed Metric Dimension of Some Path Related Graphs
IEEE Access, 2020 A vertex $k\in V_{G}$ determined two elements (vertices or edges) $\ell,m \in V_{G}\cup E_{G}$ , if $d_{G}(k,\ell)\neq d_{G}(k,m)$ . A set $R_ {\text {m}}$ of vertices in a graph $G$ is a mixed metric generator for $G$ , if two distinct elements
Hassan Raza, Ying Ji, Shaojian Qu
doaj +1 more source
Evolutionary Games of Multiplayer Cooperation on Graphs. [PDF]
PLoS Computational Biology, 2016 There has been much interest in studying evolutionary games in structured populations, often modeled as graphs. However, most analytical results so far have only been obtained for two-player or linear games, while the study of more complex multiplayer ...
Jorge Peña +3 more
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Methods in Psychology, 2021 Joint displays provide a visual means to represent the integration of qualitative and quantitative research in addition to a framework for thinking about integration and organizing data, methods, or results. Despite increases in the use of joint displays,
Timothy C. Guetterman +2 more
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Coloring Mixed and Directional Interval Graphs
, 2023 A mixed graph has a set of vertices, a set of undirected egdes, and a set of directed arcs. A proper coloring of a mixed graph $G$ is a function $c$ that assigns to each vertex in $G$ a positive integer such that, for each edge $uv$ in $G$, $c(u) \ne c(v)$ and, for each arc $uv$ in $G$, $c(u) < c(v)$. For a mixed graph $G$, the chromatic number $χ(G)
Grzegorz Gutowski +5 more
openaire +4 more sources
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
An upper bound for the largest singular value of extended mixed graphs
Examples and CounterexamplesAn extended mixed graph contains edges declared to be either positive, or negative, or oriented from one end to the other. They unify concepts of mixed graphs, signed graphs, oriented graphs and ordinary graphs.
Zoran Stanić
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An Overview of Knowledge Graph Reasoning: Key Technologies and Applications
Journal of Sensor and Actuator Networks, 2022 In recent years, with the rapid development of Internet technology and applications, the scale of Internet data has exploded, which contains a significant amount of valuable knowledge.
Yonghong Chen +6 more
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source