Results 71 to 80 of about 6,114,735 (276)

Clinical leadership in service redesign using Clinical Commissioning Groups: a mixed-methods study [PDF]

, 2018
Background: A core component of the Health and Social Care Act 2012 (Great Britain. Health and Social Care Act 2012. London: HMSO; 2012) was the idea of devolving to general practitioners (GPs) a health service leadership role for service redesign.
Abbott, Aveling, Battilana, Bourgeault, British Medical Association, Care Quality Commission, Checkland, Cloutier, Coombs, Currie, Currie, Cyert, Darzi, Denis, Denis, Denis, Dent, Department of Health, Dickinson, DiMaggio, Edwards, Eisenhardt, Eisenhardt, Field, Fitzgerald, Francis, Glaser, Great Britain, Great Britain, Greenhalgh, Greenwood, Greenwood, Gronn, Guthrie, Guthrie, Ham, Hartley, Heifetz, Heifetz, Heracleous, Ibarra, Imison, Ipsos, Kellog, Klein, Lawrence, Lawrence, Lawrence, Le Grand, Lincoln, Mays, McNulty, Miles, Miller, Moon, National Improvement and Leadership Development Board, Newman, NHS Confederation, NHS England, NHS England, NHS England, NHS England, NHS England, NHS England, NHS England and NHS Improvement, Packwood, PricewaterhouseCoopers, Radnor, Reay, Robertson, Robertson, Saks, Sanders, Seo, Sharpe, Sheaff, Smith, Spillane, Spurgeon, Storey, Storey, Storey, Storey, Storey, The Academy of Medical Sciences, The Health Foundation, The King’s Fund, Thornton, Touati, West, Williams   +90 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Differences between frequent emergency department users in a secondary rural hospital and a tertiary suburban hospital in central Japan: a prevalence study

BMJ Open, 2020
Objectives Although frequent emergency department (ED) use is a global issue, little research has been conducted in a country like Japan where universal health insurance is available. The study aims to (1) document the proportion of ED visits that are by
Makoto Kaneko, Masashi Okubo, Michael D Fetters, Machiko Inoue, Allison K Cullen Furgal, Benjamin F Crabtree   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

When Quantitative or Qualitative Data Are Not Enough: Application of Mixed Methods Research in Medical Education

MedEdPORTAL, 2008
Introduction Mixed methods research, collecting and analyzing both qualitative and quantitative data in a single study, is an effective approach for expanding and triangulating research findings, particularly in complex, real-world situations and ...
Karen Schifferdecker
doaj   +1 more source

Mixed semi-Lagrangian/finite difference methods for plasma simulations [PDF]

, 2014
In this paper, we present an efficient algorithm for the long time behavior of plasma simulations. We will focus on 4D drift-kinetic model, where the plasma's motion occurs in the plane perpendicular to the magnetic field and can be governed by the 2D ...
Filbet, Francis, Yang, Chang
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Mixed methods in health care research. Paradigms and philosphy [PDF]

, 2018
When to use mixed methods is one of the most challenging issues that health care researchers currently face. The predominance of quantitative methods have not been enough to respond to many relevant questions on health care, that need a multiple approach.
Kendall, Sally
core