Results 81 to 90 of about 6,114,735 (276)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Telemedicine Training in Undergraduate Medical Education: Mixed-Methods Review. [PDF]
, 2019 BACKGROUND: Telemedicine has grown exponentially in the United States over the past few decades, and contemporary trends in the health care environment are serving to fuel this growth into the future.
Dicker, MD, PhD, FASTRO, Adam P. +1 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Convergence and Optimality of Adaptive Mixed Methods on Surfaces [PDF]
, 2014 In a 1988 article, Dziuk introduced a nodal finite element method for the Laplace-Beltrami equation on 2-surfaces approximated by a piecewise-linear triangulation, initiating a line of research into surface finite element methods (SFEM). Demlow and Dziuk
Holst, Michael +2 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Numerical Experiments for Darcy Flow on a Surface Using Mixed Exterior Calculus Methods [PDF]
, 2011 There are very few results on mixed finite element methods on surfaces. A theory for the study of such methods was given recently by Holst and Stern, using a variational crimes framework in the context of finite element exterior calculus. However, we are
Hirani, Anil N., Kalyanaraman, Kaushik
core
Mixed finite element methods for linear elasticity with weakly imposed symmetry
, 2007 In this paper, we construct new finite element methods for the approximation of the equations of linear elasticity in three space dimensions that produce direct approximations to both stresses and displacements.
Arnold, Douglas N. +2 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Primal dual mixed finite element methods for indefinite advection--diffusion equations [PDF]
, 2018 We consider primal-dual mixed finite element methods for the advection--diffusion equation. For the primal variable we use standard continuous finite element space and for the flux we use the Raviart-Thomas space.
Burman, Erik, He, Cuiyu
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source