Results 81 to 90 of about 5,584,216 (285)

Perceived Family Support, Acculturation, and Life Satisfaction in Mexican American Youth: A Mixed-Methods Exploration [PDF]

open access: yes, 2006
In this article, the authors describe a mixed-methods study designed to explore perceived family support, acculturation, and life satisfaction among 266 Mexican American adolescents.
Edwards, Lisa, Lopez, Shane J.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Barriers and facilitators to HPV vaccination in primary care practices: A mixed methods study using the Consolidated Framework for Implementation Research [PDF]

open access: yes, 2018
Background In the United States, the effective, safe huma papilloma virus (HPV) vaccine is underused and opportunities to prevent cancer continue to be missed.
Dodd, Sherry   +5 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Development and Validation of a Circumplex-Based Affective-State Scale for First-Year Engineering Students

open access: yesEducation Sciences
Despite growing awareness of the emotional challenges faced by engineering students and their impact on academic performance and retention, the field lacks validated tools to systematically assess affective states in theoretically grounded ways.
Gibin Mannathikulathil Raju   +2 more
doaj   +1 more source

Mixed-methods in brand research: the relationship between metaphors, settings and behaviour [PDF]

open access: yes
People describe with words their thoughts but sometimes it is not really easy to describe a concept especially when it is not so clear in the mind of the person too.
D'ALVANO, CHIARA
core  

ADRIC: Adverse Drug Reactions In Children - a programme of research using mixed methods [PDF]

open access: yes, 2014
Aims To comprehensively investigate the incidence, nature and risk factors of adverse drug reactions (ADRs) in a hospital-based population of children, with rigorous assessment of causality, severity and avoidability, and to assess the consequent ...
Arnott, Janine   +14 more
core  

Does quantitative research in child maltreatment tell the whole story? The need for mixed-methods approaches to explore the effects of maltreatment in infancy [PDF]

open access: yes, 2016
Background and Aims. Research on child maltreatment has largely overlooked the under-five age group and focuses primarily on quantitative measurement.
Gajwani, Ruchika   +2 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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