Results 101 to 110 of about 2,955,171 (326)
On the Statistical Mechanics and Surface Tensions of Binary Mixtures
, 2005 Within a lattice model describing a binary mixture with fixed concentrations of the species we discuss the relation-ship between the surface tension of the mixture and the ...
De Coninck, Joël +2 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
depmixS4: An R Package for Hidden Markov Models
Journal of Statistical Software, 2010 depmixS4 implements a general framework for defining and estimating dependent mixture models in the R programming language. This includes standard Markov models, latent/hidden Markov models, and latent class and finite mixture distribution models.
Ingmar Visser, Maarten Speekenbrink
doaj
Effects of fracture network connectivity in coal seams on proppant transport
Meitan kexue jishuThe horizontal well staged multi-cluster fracturing used in the development of coalbed methane could jointly form a complex fracture network with cleats in the coal seam.
Jiaxiang XU +4 more
doaj +1 more source
Robust estimation of mixing measures in finite mixture models [PDF]
, 2017 Nhat Ho +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Statistical analysis for a penalized EM algorithm in high-dimensional mixture linear regression model [PDF]
, 2023 Ning Wang, Xin Zhang, Qing Mai
openalex +1 more source
Flexible Rasch Mixture Models with Package psychomix [PDF]
Measurement invariance is an important assumption in the Rasch model and mixture models constitute a flexible way of checking for a violation of this assumption by detecting unobserved heterogeneity in item response data.
Achim Zeileis +3 more
core